Sleep Medicine & Chronobiology

Cardiopulmonary coupling, sleep-stage instability and wearable-derived measures of sleep quality in psychiatric and neurodegenerative disease.

Figure 2 from “Efficient Screening in Obstructive Sleep Apnea Using Sequential Machine Learning Models, Questionnaires, and Pulse Oximetry Signals: Mixed Methods Study”

Efficient Screening in Obstructive Sleep Apnea Using Sequential Machine Learning Models, Questionnaires, and Pulse Oximetry Signals: Mixed Methods Study

21 publications

2024

Efficient Screening in Obstructive Sleep Apnea Using Sequential Machine Learning Models, Questionnaires, and Pulse Oximetry Signals: Mixed Methods Study

Kuo NY, Tsai HJ, Tsai SJ, Yang AC. Journal of medical Internet research26:e51615.

Full text · PMC doi:10.2196/51615

Both models demonstrated adequate at-home screening capabilities for sleep disorders, particularly for patients unsuitable for in-laboratory sleep studies.

Senior authorHigh impact

2023

Adenotonsillectomy-related changes in systemic inflammation among children with obstructive sleep apnea

Huang CG, Hsu JF, Chuang LP, Li HY, Fang TJ, … Chuang HH (12 authors). Journal of the Chinese Medical Association : JCMA86(6):596-605.

Full text · PMC doi:10.1097/JCMA.0000000000000921

These preliminary findings suggest that systemic inflammation is not only a complication of OSA but also that it mediates the surgical effects, which may open avenues for potential interventions to reduce tonsil size and OSA severity through the regulation of IL-8 and CCL5.

Dietary profile of pediatric obstructive sleep apnea patients, effects of routine educational counseling, and predictors for outcomes

Chuang HH, Lin RH, Hsu JF, Chuang LP, Li HY, … Lee LA (12 authors). Frontiers in public health11:1160647.

Full text · PMC doi:10.3389/fpubh.2023.1160647

This study aimed to investigate the dietary profile of pediatric OSA patients, effects of educational counseling after adenotonsillectomy, and predictor for disease resolution.

Multitask Learning for Automated Sleep Staging and Wearable Technology Integration

Chih HY, Ahmed T, Chiu AP, Liu YT, Kuo HF, … Lien DH (7 authors). Advanced Intelligent Systems.

doi:10.1002/aisy.202300270

A multitask deep-learning model performs automated sleep staging and integrates with wearable technology, enabling efficient sleep monitoring outside the traditional polysomnography laboratory.

2022

Effectiveness of Digital Cognitive Behavioral Therapy for Insomnia in Young People: Preliminary Findings from Systematic Review and Meta-Analysis

Tsai HJ, Yang AC, Zhu JD, Hsu YY, Hsu TF, Tsai SJ. Journal of personalized medicine12(3).

Full text · PMC doi:10.3390/jpm12030481

These preliminary findings from the meta-analysis suggest that dCBT-i is a moderately effective treatment in managing insomnia in younger age groups, and CBT-i delivered through the web or a mobile application is an acceptable approach for promoting sleep health in young people.

2021

An association study in the Taiwan Biobank elicits the GABAA receptor genes GABRB3, GABRA5, and GABRG3 as candidate loci for sleep duration in the Taiwanese population

Hou SJ, Tsai SJ, Kuo PH, Lin WY, Liu YL, … Lan TH (8 authors). BMC medical genomics14(1):223.

Full text · PMC doi:10.1186/s12920-021-01083-x

Our results indicate that rs189790076 in GABRA5 and gene-gene interactions among GABRB3, GABRA5, and GABRG3 may contribute to sleep duration in the Taiwanese population.

Difficulty in initiating sleep is associated with poor morning cardiovascular function

Tsai HJ, Kuo TBJ, Yang AC, Tsai SJ, Yang CCH. Psychiatry research295:113518.

doi:10.1016/j.psychres.2020.113518

This study explored morning cardiovascular function in individuals with sleep-onset insomnia by analysing heart rate variability (HRV), blood pressure variability, and baroreflex sensitivity.

2020

An association study in the Taiwan Biobank reveals RORA as a novel locus for sleep duration in the Taiwanese Population

Hou SJ, Tsai SJ, Kuo PH, Liu YL, Yang AC, … Lan TH (7 authors). Sleep medicine73:70-75.

doi:10.1016/j.sleep.2020.04.008

Our results indicate that the circadian clock gene RORA may contribute to sleep duration independently as well as through gene-gene and gene-environment interactions in the Taiwanese population.

2018

The Effects of Tai Chi on Sleep Quality in Chinese American Patients With Major Depressive Disorder: A Pilot Study

Ma Y, Yeung A, Yang AC, Peng CK, Clain A, … Yeung AS (8 authors). Behavioral sleep medicine16(4):398-411.

doi:10.1080/15402002.2016.1228643

This pilot study evaluated the effects of Tai Chi training on sleep quality (primary outcomes), and depression and social functioning levels (secondary outcomes) among patients with depression.

2017

Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population

Lin E, Kuo PH, Liu YL, Yang AC, Kao CF, Tsai SJ. Oncotarget8(15):24088-24098.

Full text · PMC doi:10.18632/oncotarget.15493

In this study, we assessed whether 11 circadian clockgenes are associated with cognitive aging independently and/or through complex interactions in an old Taiwanese population.

Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis

Lin E, Kuo PH, Liu YL, Yang AC, Kao CF, Tsai SJ. PloS one12(3):e0173861.

Full text · PMC doi:10.1371/journal.pone.0173861

Additionally, we found interactions among the ARNTL rs10832020, GSK3B rs2199503, PER3 rs10746473, RORA rs8034880, and RORB rs972902 SNPs influenced MetS (P < 0.001 ~ P = 0.002).

Increased Risk of Myofascial Pain Syndrome Among Patients with Insomnia

Lin WC, Shen CC, Tsai SJ, Yang AC. Pain medicine (Malden, Mass.)18(8):1557-1565.

doi:10.1093/pm/pnw300

Malignant neoplasm (hazard ratio = 3.08) and living in urban areas (hazard ratio = 3.05) were identified as independent risk factors for myofascial pain syndrome in patients with insomnia.

Senior author

Quality and readability of online information resources on insomnia

Ma Y, Yang AC, Duan Y, Dong M, Yeung AS. Frontiers of medicine11(3):423-431.

doi:10.1007/s11684-017-0524-9

This study aimed to evaluate the quality and readability of insomnia-related online information.

2015

Publication analysis on insomnia: how much has been done in the past two decades?

Ma Y, Dong M, Mita C, Sun S, Peng CK, Yang AC. Sleep medicine16(7):820-6.

doi:10.1016/j.sleep.2014.12.028

Furthermore, we found that while studies on drug therapy and adverse effects decreased in the most recent five years, the greatest expansion of insomnia publications were in the areas of cognitive behavioral therapy for insomnia (CBT-I) and alternative therapies.

Senior author

2014

Local awakening: regional reorganizations of brain oscillations after sleep

Tsai PJ, Chen SC, Hsu CY, Wu CW, Wu YC, … Lin CP (10 authors). NeuroImage102 Pt 2:894-903.

doi:10.1016/j.neuroimage.2014.07.032

In conclusion, the regional specificity and the stage effect were verified in support of the local awakening concept, indicating that sleep regulation leads to the reorganization of brain networks upon awakening.

High impact

Pisa syndrome after discontinuation of clotiapine in a patient with intractable insomnia

Wang EH, Yang AC. Journal of clinical psychopharmacology34(2):276-7.

doi:10.1097/JCP.0000000000000045

Case report of Pisa syndrome (tonic lateral trunk flexion) emerging after clotiapine discontinuation in a patient with intractable insomnia.

Senior author

Sleep apnea and the subsequent risk of breast cancer in women: a nationwide population-based cohort study

Chang WP, Liu ME, Chang WC, Yang AC, Ku YC, … Tsai SJ (8 authors). Sleep medicine15(9):1016-20.

doi:10.1016/j.sleep.2014.05.026

Despite not meeting statistical significance, we found increases in the risk of breast cancer in women aged 30-59 years (HR, 2.06; 95% CI, 0.90-4.70) and ≥60 years (HR, 3.05; 95% CI, 0.90-10.32) compared with those aged 0-29 years.

2013

Daytime sleepiness: a risk factor for poor social engagement among the elderly

Lee YT, Tsai CF, Ouyang WC, Yang AC, Yang CH, Hwang JP. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society13(4):213-20.

doi:10.1111/psyg.12020

The aim of this study was to investigate the relationship between social engagement and daytime sleepiness among aged residents of a veterans' housing facility in Taiwan.

Physiologic and laboratory correlates of depression, anxiety, and poor sleep in liver cirrhosis

Ko FY, Yang AC, Tsai SJ, Zhou Y, Xu LM. BMC gastroenterology13:18.

Full text · PMC doi:10.1186/1471-230X-13-18

Increased serum AST and abnormal autonomic nervous activities by HRV analysis were associated with psychological distress in cirrhosis.

Sleep apnea and the risk of dementia: a population-based 5-year follow-up study in Taiwan

Chang WP, Liu ME, Chang WC, Yang AC, Ku YC, … Tsai SJ (8 authors). PloS one8(10):e78655.

Full text · PMC doi:10.1371/journal.pone.0078655

The SA patients in this study had a 1.70-times greater risk of developing dementia within 5 years of diagnosis compared to non-SA age- and sex-matched patients, after adjusting for other risk factors (95% confidence interval (CI) = 1.26-2.31; P < .01).

2011

Reduced physiologic complexity is associated with poor sleep in patients with major depression and primary insomnia

Yang AC, Tsai SJ, Yang CH, Kuo CH, Chen TJ, Hong CJ. Journal of affective disorders131(1-3):179-85.

doi:10.1016/j.jad.2010.11.030

These findings could highlight the importance of treating insomnia as an independent disease rather than a symptom.

First author