Publications
Compiled from PubMed and reconciled against the laboratory’s full-text archive. 96 are marked selected — first-author, senior-author or high-impact work.
These findings support its potential as an indirect biomarker of neurobiological alterations.
doi:10.4103/ejpi.EJPI-D-25-00066
A review mapping how digital medicine — wearables, AI and big data — is reshaping neuropsychiatry and enabling an emerging framework of precision psychiatry.
Full text · PMCdoi:10.1155/prm/5504074
HHSA revealed two dominant cross-frequency interactions within the alpha-carrier band (8-16 Hz): one modulated by 3-6-Hz (high-delta to theta) and another by 1-2-Hz (low-delta) oscillations, indicating layered modulation under anesthesia.
PDFdoi:10.1007/s00406-025-02161-2
Our findings suggested active cognitive rehabilitation to patients with schizophrenia throughout the course of illness may be warranted.
Full text · PMCdoi:10.1093/ehjdh/ztaf003
Cox regression analyses showed that LVH identified by AI algorithm (hazard ratio and 95% confidence interval: 1.587, 1.309-1.924), Sokolow-Lyon (1.19, 1.038-1.365), Cornell product (1.301, 1.124-1.505), Cornell/strain index (1.306, 1.185-1.439), Framingham criterion (1.174, 1.062-1.298), and echocardiography-confirmed LVH (1.124, 1.019-1.239) were all significantly associated with mortality.
Full text · PMCdoi:10.1038/s41467-025-58506-x
Our findings elucidate the complex relationships between IR surrogate markers, genetic predisposition, and disease phenotypes in the Taiwanese population, contributing valuable insights to the field of metabolic research.
Full text · PMCdoi:10.1111/pcn.13780
However, these results do not remain after Bonferroni correction.
Full text · PMCdoi:10.1017/S0033291725101517
These findings highlight the potential of brain aging trajectories as biomarkers for BD and MDD, offering insights into distinct and overlapping neuroanatomical changes.
doi:10.1016/j.pnpbp.2025.111270
Following genome-wide association tests, we found genetic variants and SNP-mapped genes and verified the areal preferential expression profiles in the developing human and mouse neocortex.
Full text · PMCdoi:10.1002/brb3.70688
Further, single-cell RNA sequencing and in situ hybridization analyses revealed dynamic expression patterns of the schizophrenia-associated genes during cortical development, suggesting their potential roles in the structural abnormalities observed in schizophrenia.
doi:10.1016/j.biopsycho.2025.109101
Our findings reveal that active neural interactions or modulations during wakefulness and REM sleep are characterized by super-Gaussian iPDF patterns.
Full text · PMCdoi:10.1016/j.ynirp.2025.100246
MRI analysis revealed significant differences in brain regions, including the posterior cingulate gyrus, lenticular nucleus, olfactory cortex, and cerebellum.
Full text · PMCdoi:10.2196/51615
Both models demonstrated adequate at-home screening capabilities for sleep disorders, particularly for patients unsuitable for in-laboratory sleep studies.
doi:10.1016/bs.pbr.2024.07.003
Analysis of pixel value histograms demonstrated varying degrees of similarity, as measured by the Structural Similarity Index (SSIM), between raw and generated features across different facial features.
Full text · PMCdoi:10.1186/s13195-024-01448-1
For the structural randomness, we found significant decreases in the temporal and subcortical areas and significant increases in the occipital and frontal regions.
doi:10.1016/j.neuroimage.2024.120540
These results underscore the importance of exploring timescales of BOLD signals when constructing FBN and highlight the relevance of specific intrinsic FBNs to aging and cognitive performance.
Full text · PMCdoi:10.1186/s12888-024-06228-7
Our findings revealed a noteworthy sex-by-diagnosis interaction, with male individuals with bipolar I disorder displaying larger gray matter volume and altered functional connectivity in the limbic system compared to female individuals with bipolar I disorder and healthy participants.
Full text · PMCdoi:10.1097/JCMA.0000000000001116
We found nine core subjects, constituting four different learning pathways.
Full text · PMCdoi:10.2196/47803
In conclusion, this study successfully used machine learning methodologies, particularly the LightGBM model, to differentiate SR and AF based on power spectral features derived from 12-lead ECGs.
Accurate predictions of postoperative pain intensity are necessary for customizing analgesia plans.
We investigated all suicide cases in 2007-2017 identified from the national cause-of-death data files, with each suicide case matched to 10 controls by age and sex and each suicide case/control assigned to one of the 355 townships across Taiwan.
Full text · PMCdoi:10.1097/JCMA.0000000000000921
These preliminary findings suggest that systemic inflammation is not only a complication of OSA but also that it mediates the surgical effects, which may open avenues for potential interventions to reduce tonsil size and OSA severity through the regulation of IL-8 and CCL5.
Our findings, by shedding light on the underlying transmission mechanism of infectious diseases, suggest that causal inference analysis is a promising approach to determine epidemiological interventions.
Full text · PMCdoi:10.3389/fpubh.2023.1160647
This study aimed to investigate the dietary profile of pediatric OSA patients, effects of educational counseling after adenotonsillectomy, and predictor for disease resolution.
Full text · PMCdoi:10.3389/fpsyt.2023.1305359
Pair-wise brain regions with significantly different functional connectivity among the two groups were identified and further analyzed for their concurrent ratio of connectomic differences with another solitary brain region (single-FC dysfunction) or dynamically interconnected brain network (network-FC dysfunction).
Full text · PMCdoi:10.1038/s41398-023-02379-5
Our findings provided more insights into schizophrenia neuropathology.
doi:10.1038/s41397-023-00298-8
In conclusion, we identified loci that may affect the clinical response to treatment with antidepressants in the context of empirically defined depressive syndromal factors and side effects among the Taiwanese Han population, thus providing novel biological targets for further investigation.
A multitask deep-learning model performs automated sleep staging and integrates with wearable technology, enabling efficient sleep monitoring outside the traditional polysomnography laboratory.
Full text · PMCdoi:10.1017/S0033291722003361
Our findings of high PAF from major depressive disorder, dysthymia, and sleep disorder to youth suicides suggest that youth suicide prevention that focuses on detecting and treating mental illness may usefully target these disorders.
Full text · PMCdoi:10.1038/s41537-022-00325-w
Our findings suggest that schizophrenia differentially affects the decline of different brain structures during the disease course.
Full text · PMCdoi:10.1038/s41537-022-00328-7
Schizophrenia is a chronic brain disorder, and neuroimaging abnormalities have been reported in different stages of the illness for decades.
doi:10.1016/j.jpba.2023.115456
Our previous study demonstrated a surface-enhanced Raman scattering (SERS)-based approach to identify nicotine-containing e-liquids; without any pre-treatment, e-liquid can be directly tested on our solid-phase SERS substrates, made of silver nanoparticle arrays embedded in anodic aluminium oxide nanochannels (Ag/AAO).
Full text · PMCdoi:10.1038/s41598-023-38214-6
In conclusion, sleep quality and distinction between wake- and sleep-related autonomic function may be biomarkers for early AD detection.
doi:10.1016/j.jpsychires.2023.03.023
Our findings indicated that pre-treatment, right-side cortical hyperactivation is associated with poor outcomes of antidepressant-based or ECT-based treatment in major depression.
doi:10.1007/s00415-023-11909-6
While our preliminary study suggests that NOTCH3 p.R544C may influence blood pressure, stroke, and dementia in the Taiwan Biobank, replication in a well-powered external sample is required.
Full text · PMCdoi:10.3389/fpubh.2023.1103085
Multivariable linear regression models in the baseline analysis revealed independent relationships between tonsil size and obstructive apnea-hypopnea index (OAHI), adenoidal-nasopharyngeal ratio and very low frequency (VLF) power of HRV (an indicator of sympathetic activity), and normalized low frequency power (an indicator of sympathetic activity) and OAHI.
doi:10.1097/PSY.0000000000001079
Autonomic neural controls in sleep regulation have been previously demonstrated; however, whether these alternations can be observed by different sleep staging approaches remains unclear.
age-related neurovascular structural and functional impairment is a major aetiology of dementia and stroke in older people.
Full text · PMCdoi:10.3390/jpm12030481
These preliminary findings from the meta-analysis suggest that dCBT-i is a moderately effective treatment in managing insomnia in younger age groups, and CBT-i delivered through the web or a mobile application is an acceptable approach for promoting sleep health in young people.
Full text · PMCdoi:10.3389/fnagi.2022.885090
Results: The homozygous major allele of rs2298813 was associated with larger volumes in the right putamen (p = 0.0442) and right pallidum (p = 0.0346).
Full text · PMCdoi:10.1177/17562864221138154
These findings can assist clinicians in predicting changes in cognitive status in individuals with a high risk of Alzheimer's disease and can assist future studies in developing precise treatment and prevention strategies.
Full text · PMCdoi:10.1186/s12888-022-03723-7
Furthermore, a sex-based subgroup analysis revealed that the risk of hip fracture remained significantly higher in female patients with schizophrenia (HR: 2.68, 95% CI: 1.32-5.44) than in female controls.
Full text · PMCdoi:10.1038/s41467-022-30360-1
Author reply defending empirical-mode-decomposition causal analysis against published critiques, clarifying when it correctly distinguishes causation from shared external forcing.
Full text · PMCdoi:10.1016/j.eclinm.2022.101543
Our results show that the proposed method provides sufficient treatment recommendations that are comparable to those of specialists.
doi:10.1016/j.jfma.2022.02.011
Patients with depressive disorders were identified based on International Classification of Diseases codes.
Full text · PMCdoi:10.1097/JCMA.0000000000000710
People may experience tinnitus after sudden hearing impairment.
doi:10.1016/j.schres.2021.08.026
These findings suggest that schizophrenia has abnormal brain signal complexity linked to psychotic symptoms.
Full text · PMCdoi:10.1186/s12920-021-01083-x
Our results indicate that rs189790076 in GABRA5 and gene-gene interactions among GABRB3, GABRA5, and GABRG3 may contribute to sleep duration in the Taiwanese population.
Full text · PMCdoi:10.18632/aging.203321
Our study suggests that genetic variants in the dopamine receptor-related loci may influence cognitive aging individually and by means of gene-physical activity interactions.
Full text · PMCdoi:10.3389/fpsyt.2021.655292
This study aimed to differentiate between patients with FES and healthy controls (HCs) on basis of the frontotemporal activity measured by NIRS with a support vector machine (SVM) and deep neural network (DNN) classifier.
Full text · PMCdoi:10.3389/fnagi.2021.625931
Our findings show that comparing to gyri, the sulcal thinning is the most prominent pattern during the aging process, and the gyrification of pial and white matter surfaces were also affected differently, which implies the vulnerability of functional segregation during aging.
doi:10.1016/j.psychres.2020.113518
This study explored morning cardiovascular function in individuals with sleep-onset insomnia by analysing heart rate variability (HRV), blood pressure variability, and baroreflex sensitivity.
From our analysis, we generalize to the Taiwanese population genome-wide significant associations with height and 18 previously identified genes in European and non-Taiwanese East Asian populations.
Full text · PMCdoi:10.3389/fnagi.2021.623930
Conclusion: The present study suggests that EEG power correlates to behavioral and psychological symptoms among patients with mild Alzheimer's disease.
Full text · PMCdoi:10.2196/24554
We found that fever, gastroenteritis, poison, cruise, wedding, and watery diarrhea were important factors correlated with norovirus Google Trends.
Full text · PMCdoi:10.3390/jpm11070597
Our study suggests that an integrated machine learning and genome-wide analysis approach may offer an advantageous method to establish bioinformatics tools for discriminating MDD patients from healthy controls.
This study aimed to explore whether complexity measures of electroencephalogram (EEG) signals vary across the frontal region between patients with or without remission in depression.
Full text · PMCdoi:10.1161/JAHA.121.021585
Mediation analysis revealed a significant mediation effect between HRV and GHF in addition to their respective detrimental effects on survival.
Full text · PMCdoi:10.3390/jpm11121316
In emulation of clinical trials, the model-selected regimen was associated with a reduced treatment failure rate.
Except for passive smoking, all smoking measurements were associated with FG, HbA1c, and diabetes (P < 0.0033) and were associated with an exacerbation of the genetic risk of FG and HbA1c (P Interaction < 0.0033).
doi:10.1016/j.psychres.2020.113257
Research suggests that the aging relates to variability of resting-state fMRI (rs-fMRI) signal and the functional connectivity.
doi:10.1016/j.sleep.2020.04.008
Our results indicate that the circadian clock gene RORA may contribute to sleep duration independently as well as through gene-gene and gene-environment interactions in the Taiwanese population.
This study provides evidence for the genetic overlap between schizophrenia and tobacco use in women, and this overlap was stronger in the younger population.
To go beyond the disconnectivity hypothesis of schizophrenia, directed (effective) connectivity was measured between 94 brain regions, to provide evidence on the source of the changes in schizophrenia and a mechanistic model.
Full text · PMCdoi:10.1038/s41598-020-75199-y
We found that one or two copies of the G allele in rs671 (ALDH2) increased the risk of excessive alcohol consumption, while one or two copies of the C allele in rs3782886 (BRAP) reduced the risk of excessive alcohol consumption.
Full text · PMCdoi:10.3389/fpsyt.2020.531801
Results demonstrated that AD patients had lower complexity on short time scales and higher complexity on long time scales in the alpha band in temporal regions of the brain.
Full text · PMCdoi:10.3389/fpsyt.2020.542394
Discussion: Together, our approach under the EDNN framework demonstrated the potential future direction of making a schizophrenia diagnosis based on structural brain imaging data.
Full text · PMCdoi:10.3389/fnins.2020.00337
Editorial introducing advances in multi-scale entropy and complexity analysis of brain signals across neuroimaging modalities.
Full text · PMCdoi:10.1093/schbul/sbz062
These findings provide direct evidence for the disconnection hypothesis of schizophrenia, suggesting that abnormalities in the basal ganglia-thalamus-cortex circuit can be used as a biomarker of schizophrenia.
Full text · PMCdoi:10.3389/fphar.2020.559601
From two MDD groups in the antidepressant therapeutic response, by using gene-based analyses, we have identified 14 polymorphisms as suggestive markers for therapeutic response (13 for remission and 1 for response) in both meta- and mega-analyses.
doi:10.1007/s10877-019-00450-5
For baseline HRV analysis, we found significant differences in the RMSSD (p = 0.043), pNN50 (p = 0.029), VLF power (p = 0.035), LF power (p = 0.004), and HF power (p = 0.037) between the good and poor sleeper groups.
These findings provide empirical evidence supporting the estimation of brain age from a brain network perspective, and demonstrate the clinical feasibility of evaluating neurological diseases hypothesized to be associated with accelerated brain aging.
Full text · PMCdoi:10.3390/ph13100305
Our study demonstrates that the ensemble machine learning framework may present a useful technique to create bioinformatics tools for discriminating non-responders from responders prior to antidepressant treatments.
Full text · PMCdoi:10.1186/s12883-020-01916-9
From Taiwan's National Health Insurance Research Database, we identified the data of patients newly diagnosed as having gout between January 1, 2000 and December 1, 2000.
Full text · PMCdoi:10.3390/ijms21062194
Major depressive disorder (MDD), which is a leading psychiatric illness across the world, severely affects quality of life and causes an increased incidence of suicide.
Previous studies have shown that men and women have different genetic architectures across many traits.
doi:10.1016/j.psychres.2020.113454
Our findings suggest that patients with RLS and PLMS have poorer subjective sleep and mood scales.
Full text · PMCdoi:10.3389/fpsyt.2020.00606
The association between tinnitus and anxiety disorder remains debated.
Full text · PMCdoi:10.1038/s41598-020-69243-0
Our results indicate an association between tinnitus and higher risk of developing AD and PD.
doi:10.1016/j.schres.2019.10.034
These findings suggest a highly individualized pattern of structural dysconnectivity underlies the heterogeneity of schizophrenia, but these disruptions likely converge on an emergent common pathway to generate the clinical phenotype of the disorder.
doi:10.1016/j.bpsc.2020.01.010
These findings suggest that prominent psychiatric disorders share common impairments, possibly linked to perception and motor output, as well as unique dysconnectivity profiles that hypothetically mediate the more distinctive features of the disorder-specific psychopathology.
doi:10.1016/j.neuroimage.2018.12.032
To demonstrate the utility of sKPCR for real data analysis, we have also compared sKPCR with the above methods based on the identification of voxel-wise differences between schizophrenic patients and healthy controls in four independent rsfMRI datasets.
Full text · PMCdoi:10.3389/fneur.2019.01065
Evidence suggests that the neuro-inflammation mechanisms associated with interleukin-12 (IL-12) may be linked to Alzheimer's diseases and cognitive aging.
Logistic regression analyses with the adjustment of demographic data revealed that the unaffected siblings of patients with schizophrenia were more likely to develop T2DM (odds ratio [OR]: 1.39, 95% confidence interval [CI]: 1.10-1.75) later in life compared with the control group.
Full text · PMCdoi:10.1371/journal.pgen.1008277
Our findings show that the genetic effects on obesity measures can be decreased to various extents by performing different kinds of exercise.
doi:10.1016/j.dnarep.2019.03.013
Additionally, we found that interactions between the EXO1 and RAD51C genes influenced cognitive aging (P = 0.002).
Full text · PMCdoi:10.3389/fpsyt.2019.00481
The chronic autoimmune disease myasthenia gravis (MG) is characterized by fluctuating muscle weakness, which can lead to a large amount of stress in the patient.
doi:10.1080/0895769X.2019.1675491
A computational stylometric approach is used to test and validate the enlarged canon of works attributed to the Elizabethan playwright Thomas Kyd, applying quantitative text-analysis methods to questions of literary authorship.
Full text · PMCdoi:10.3389/fpsyt.2018.00290
By using the SNP dataset that was original to a genome-wide association study, we selected 10 SNPs (including ABCA13 rs4917029, BNIP3 rs9419139, CACNA1E rs704329, EXOC4 rs6978272, GRIN2B rs7954376, LHFPL3 rs4352778, NELL1 rs2139423, NUAK1 rs2956406, PREX1 rs4810894, and SLIT3 rs139863958) which were associated with antidepressant treatment response.
Full text · PMCdoi:10.3389/fnins.2018.00398
Furthermore, an increased relative error of SampEn was associated with an increased coefficient of variation in voxel-wise statistics.
Full text · PMCdoi:10.1371/journal.pone.0200682
Patients who experienced a stroke during the follow-up period were identified.
Full text · PMCdoi:10.1016/j.nicl.2018.08.027
We replicated these findings using an automated anatomical labeling atlas to define the network node.
Full text · PMCdoi:10.1038/s41467-018-05845-7
Furthermore, we demonstrate the generic applicability of our method to both stochastic and deterministic systems, and show the consistency of causal-decomposition method compared to existing methods, and finally uncover the key mode of causal interactions in both modelled and actual predator-prey systems.
Full text · PMCdoi:10.1371/journal.pone.0191202
Our results show that, among these modalities, fMRI has the most significant featureby calculating the Jaccard similarity coefficient (0.7416) and Kappa index (0.4833).
doi:10.1016/j.bpsc.2017.10.004
Moreover, we show how the approach can be used to measure the differences in effective connectivity between different groups of individuals, using as an example effective connectivity in the healthy brain and in individuals with depression.
doi:10.1016/j.neurobiolaging.2018.06.007
These findings indicate that resting-state fMRI signal modulations are dynamic during the normal aging process.
doi:10.1016/j.pnpbp.2018.05.020
These results provide further evidence that abnormal variability and lateralization exist in schizophrenia patients, and abnormality in fusiform, lingual and inferior temporal could have potential help to identify the dysfunctional brain lateralization in schizophrenia.
Full text · PMCdoi:10.1093/scan/nsy032
To analyse the functioning of the amygdala in depression, we performed the first voxel-level resting state functional-connectivity neuroimaging analysis of depression of voxels in the amygdala with all other voxels in the brain, with 336 patients with major depressive disorder and 350 controls.
Full text · PMCdoi:10.1038/s41598-018-25529-y
For case-control association study, we found that all of these reported polymorphisms and genes did not reach a suggestive level.
Full text · PMCdoi:10.1038/s41398-018-0139-1
To analyze the functioning of the posterior cingulate cortex (PCC) in depression, we performed the first fully voxel-level resting state functional-connectivity neuroimaging analysis of depression of the PCC, with 336 patients with major depressive disorder and 350 controls.
Full text · PMCdoi:10.3389/fnins.2018.00758
Conclusions: The current findings suggest that the desynchronization of the mu wave during MR results in a local increase of mu entropy in sensorimotor areas, potentially reflecting a release from alpha inhibition.
doi:10.1016/j.smrv.2017.01.003
The analysis of electroencephalography (EEG) recordings has attracted increasing interest in recent decades and provides the pivotal scientific tool for researchers to quantitatively study brain activity during sleep, and has extended our knowledge of the fundamental mechanisms of sleep physiology.
doi:10.1016/j.neurobiolaging.2018.03.012
Our findings support that the changes in WMH volume in the healthy population follow a nonlinear pattern with age, especially in PVWMH.
doi:10.1016/j.jadohealth.2018.02.012
Our findings suggested that the public health government and clinicians should pay more attention to the TBI risk among patients with ADHD, and further indicated the importance of the optimal treatment for ADHD.
Full text · PMCdoi:10.18632/oncotarget.24780
We identified patients who were diagnosed with bipolar disorder in the Taiwan National Health Insurance Research Database.
Using psychiatric co-morbidities, we identified four variables as significant risk predictors of BPD and permitted identification of subjects with low, intermediate or high risk for BPD.
doi:10.1080/15402002.2016.1228643
This pilot study evaluated the effects of Tai Chi training on sleep quality (primary outcomes), and depression and social functioning levels (secondary outcomes) among patients with depression.
Full text · PMCdoi:10.3389/fnins.2018.00685
In this study, we aim to discover the altered spatio-temporal patterns of EEG complexity associated with AD pathology in different severity levels.
Full text · PMCdoi:10.18632/oncotarget.15269
Additionally, we found the interactions among CASS4-rs911159, EPHA-rs10952552, FERMT2-rs4901317, MEF2C-rs9293506, or SLC24A4-rs67063100 on cognitive aging (P = 0.004~0.035).
In this study, we used the Taiwan National Health Insurance Research Database (NHIRD) to test the bidirectional association between Bell's palsy and anxiety disorders.
Our findings suggest that depression is an independent risk factor for subsequent VaD.
Full text · PMCdoi:10.18632/oncotarget.20967
Additionally, we found that an interaction between the APOA5 rs662799 and COLEC12 rs16944558 SNPs influenced MetS, high triglyceride, and low HDL.
Full text · PMCdoi:10.18632/oncotarget.15493
In this study, we assessed whether 11 circadian clockgenes are associated with cognitive aging independently and/or through complex interactions in an old Taiwanese population.
Full text · PMCdoi:10.1371/journal.pone.0173861
Additionally, we found interactions among the ARNTL rs10832020, GSK3B rs2199503, PER3 rs10746473, RORA rs8034880, and RORB rs972902 SNPs influenced MetS (P < 0.001 ~ P = 0.002).
Malignant neoplasm (hazard ratio = 3.08) and living in urban areas (hazard ratio = 3.05) were identified as independent risk factors for myofascial pain syndrome in patients with insomnia.
doi:10.1016/j.physa.2016.11.106
Borrowing concepts from statistical physics, the authors define an information-based 'energy' and 'temperature' of literary texts, providing a thermodynamic-style framework to characterize the complexity and style of written language.
Full text · PMCdoi:10.1016/j.jad.2016.10.016
Furthermore, we found significant differences as well as overlaps of pathologic brain signal complexity between psychotic probands by DSM diagnoses, thus suggesting a biological approach to categorizing psychosis based on functional neuroimaging data.
Full text · PMCdoi:10.3390/ijms18081689
Schizophrenia has been primarily associated with dopamine dysfunction, and treatments have been developed that target the dopamine pathway in the central nervous system.
This study aimed to evaluate the quality and readability of insomnia-related online information.
Cox regression analysis after adjusting for demographic data and psychiatric comorbidities further showed that symptomatic menopausal transition was associated with an increased risk of developing bipolar disorder (HR 1.14, 95% CI 1.07∼1.23) among midlife women with major depression.
Full text · PMCdoi:10.1371/journal.pone.0172440
Additionally, we found that interactions between the ADAMTS9 rs9985304 and ADAMTS9 rs76346246 SNPs influenced cognitive aging (P < 0.001).
However, the 3-marker haplotype derived from the rs1713985, rs3796529, and rs7680734 SNPs in the REST gene demonstrated no association with cognitive aging.
Full text · PMCdoi:10.1038/s41598-017-14025-4
Our findings indicated that the TGF-β signaling pathway-associated genes of SMAD2 and TGFBR2 may contribute to the risk of MetS independently and through gene-gene interactions.
Full text · PMCdoi:10.1038/srep36830
Additionally, we found the interactions of APOA5 rs662799, BUD13 rs11216129, BUD13 rs623908, CETP rs820299, LIPA rs1412444, alcohol consumption, smoking status, or physical activity on MetS and its individual components.
Case report of cyclic Cushing's syndrome presenting with mood instability that mimicked bipolar disorder, highlighting endocrine causes of psychiatric presentations.
Full text · PMCdoi:10.1038/srep23362
These findings provide evidence that SORL1 rs3824968 modulates regional GM volume and is associated with brain trajectory during the adult lifespan.
Full text · PMCdoi:10.1371/journal.pone.0144935
In subgroup analysis, HRV indices demonstrated similar predictive values related to exercise capacity across various subpopulations, especially in the young.
The first brain-wide voxel-level resting state functional connectivity neuroimaging analysis of depression is reported, with 421 patients with major depressive disorder and 488 control subjects.
Full text · PMCdoi:10.1098/rsta.2015.0206
The Holo-Hilbert spectral analysis (HHSA) method is introduced to cure the deficiencies of traditional spectral analysis and to give a full informational representation of nonlinear and non-stationary data.
Full text · PMCdoi:10.1186/s10194-016-0697-7
Migraine is characterized by a series of phases (inter-ictal, pre-ictal, ictal, and post-ictal).
The importance of mental care for trauma victims would increase in the coming century, and our findings broadened another era for the end result of a widely prevalent psychiatric disorder.
We identified subjects who were newly diagnosed with AS between January 1, 2000, and December 31, 2008, in the Taiwan National Health Insurance (NHI) Research Database.
From the National Health Insurance Research Database (NHIRD) in Taiwan, we identified new SSNHL patients diagnosed by an otolaryngologist between January 01, 2000, and December 31, 2008.
Endometriosis was associated with an elevated likelihood of developing depression and anxiety disorders.
doi:10.3109/0167482X.2015.1124852
Our findings highlight that clinicians should pay particular attention to psychiatric comorbidities in PID patients.
Full text · PMCdoi:10.1186/s12885-016-2857-1
This large nationwide population-based cohort study suggests that there is no increased risk for ovarian, breast or uterine cancer among women who have PID compared to a matching population.
doi:10.1016/j.jneumeth.2015.10.009
We found that EEMD method was efficient to enhance the functional sensitivity of evoked fMRI.
Full text · PMCdoi:10.3389/fnagi.2016.00143
These results support the compensatory hypothesis of neurocognitive aging theory and reveal the DTI-fMRI relationship associated with normal aging.
Full text · PMCdoi:10.1634/theoncologist.2014-0311
We identified subjects who were diagnosed with PCOS between January 1, 2000, and December 31, 2004, in the Taiwan National Health Insurance (NHI) Research Database.
Full text · PMCdoi:10.12659/MSM.891086
Our findings suggest that loneliness and depression may have negative impacts on global and specific domains of cognitive function in non-demented elderly males.
doi:10.1016/j.jpain.2015.06.004
Our results supported a bidirectional temporal association between depression and FMS.
Using Taiwan׳s National Health Insurance Research Database, we identified 500 adolescents and young adults from 2002 to 2008 aged between 15 and 24 years with bipolar disorder and ADHD.
Full text · PMCdoi:10.1002/hbm.22763
These results collectively suggested that resting-state dynamics in schizophrenia exhibit two routes of pathologic change toward regular or random patterns, which contribute to the differences in syndrome domains of psychosis in patients with schizophrenia.
Full text · PMCdoi:10.3389/fnagi.2015.00251
Loneliness is associated with FCD changes in bilateral lingual gyri that are known to be important in social cognition.
Full text · PMCdoi:10.1186/s10194-015-0533-5
This diary-based study provides evidence to link the perception of temperature sensitivity and headache incidence in migraine patients.
doi:10.1016/j.sleep.2014.12.028
Furthermore, we found that while studies on drug therapy and adverse effects decreased in the most recent five years, the greatest expansion of insomnia publications were in the areas of cognitive behavioral therapy for insomnia (CBT-I) and alternative therapies.
Our findings highlight the need for psychiatric evaluation and intervention for patients with pSS.
Full text · PMCdoi:10.1371/journal.pone.0133283
Irritable bowel syndrome (IBS) is the most common functional gastrointestinal (GI) disorder observed in patients who visit general practitioners for GI-related complaints.
Those who developed Parkinson's disease during the follow-up period were identified.
Subjects who developed major depression, any depressive disorder, and anxiety disorders during the follow-up were identified.
doi:10.1016/j.ejim.2015.05.005
Recent studies have shown that the peripheral inflammation may cause the up-regulation of central nervous system inflammation and therefore possibly plays a vital role in the pathophysiology of subsequent psychiatric disorders.
Full text · PMCdoi:10.1371/journal.pone.0137914
Patients with late-onset depression (LOD) have been reported to run a higher risk of subsequent dementia.
doi:10.1016/j.neulet.2014.05.046
This study suggests that the APOE ɛ4 alleles contributed detrimental effects on cognitive function in the very old veterans who do not have dementia.
Full text · PMCdoi:10.1371/journal.pone.0088749
The effect size (cohen's f) revealed a small effect.
doi:10.1016/j.psyneuen.2013.09.027
Our findings supported the hypothesis that the BDNF Val66Met polymorphism may affect susceptibility to regional WMH volume and such genotype-by-WMH interaction effect is correlated with cognitive decline in non-demented elderly males, in which the Met allele plays a protective role.
Our findings suggest that the presence of two Met alleles has a protective effect on regional GM volumes in the Chinese population.
Recent resting fMRI studies have suggested that the functional connectivity of the brain's large-scale networks is associated with the cognitive decline of aging and is modulated by genetic factors.
doi:10.1016/j.neuroimage.2014.07.032
In conclusion, the regional specificity and the stage effect were verified in support of the local awakening concept, indicating that sleep regulation leads to the reorganization of brain networks upon awakening.
doi:10.1097/JCP.0000000000000045
Case report of Pisa syndrome (tonic lateral trunk flexion) emerging after clotiapine discontinuation in a patient with intractable insomnia.
doi:10.1016/j.neuroimage.2013.12.048
We found that tDCS can further increase the EEG complexity of the frontal lobe.
Full text · PMCdoi:10.1371/journal.pone.0107791
To evaluate the risk of depressive disorders among rheumatoid arthritis (RA) by using the Taiwan National Health Insurance Research Database (NHIRD).
Full text · PMCdoi:10.1371/journal.pone.0097041
We identified patients who were diagnosed with PCOS by an obstetrician-gynecologist in the Taiwan National Health Insurance Research Database.
doi:10.1016/j.sleep.2014.05.026
Despite not meeting statistical significance, we found increases in the risk of breast cancer in women aged 30-59 years (HR, 2.06; 95% CI, 0.90-4.70) and ≥60 years (HR, 3.05; 95% CI, 0.90-10.32) compared with those aged 0-29 years.
Either an increase or a decrease in temperature (0.05℃/day) following a warm period (mean temperature ≥26℃) was associated with the onset of cluster periods.
Full text · PMCdoi:10.1002/hbm.22398
These results support the compensatory recruitment hypothesis in older APOE ɛ4 carriers, and confer the impact of the APOE genotype on the temporal dynamics of brain activity in older adults.
Our findings suggest that RAB18 rs3765133 polymorphism affects the deve-lopment of specific brain regions, particularly the cerebellum, in healthy people.
doi:10.1016/j.bandc.2014.10.006
The results suggest that physical activity may be beneficial for adaptability of brain systems in tasks involving visuo-spatial information.
Our findings are the first to show that depression and anxiety may be associated with increased levels of CD8 in T-lymphocyte subsets in cirrhosis patients, suggesting that an imbalance of T-lymphocyte subsets may be a factor facilitating depression and anxiety in cirrhotic patients.
doi:10.1016/j.psychres.2013.07.034
These findings may warrant future research in using HRV as objective markers to monitor cardiovascular health and the severity of psychosis in patients with schizophrenia.
Full text · PMCdoi:10.1186/1129-2377-14-94
This study aimed to assess the autonomic function by analyzing heart rate variability (HRV) in patients with RCVS.
doi:10.1016/j.pnpbp.2013.07.022
MSE analysis revealed abnormal EEG complexity across short- and long-time scales that were correlated to cognitive and neuropsychiatric assessments.
doi:10.1016/j.pnpbp.2013.01.018
Editorial proposing 'complexity' — quantified across behaviour and brain dynamics — as a new research dimension for understanding mental illness.
doi:10.1016/j.neurobiolaging.2012.05.004
Our findings confirmed the hypothesis that complexity of BOLD activity was correlated with aging and cognitive performance based on MSE analysis, and may provide insights on how dynamics of spontaneous brain activity relates to aging and cognitive function in specific brain regions.
The aim of this study was to investigate the relationship between social engagement and daytime sleepiness among aged residents of a veterans' housing facility in Taiwan.
Full text · PMCdoi:10.1007/s11357-011-9367-5
The findings suggest that Bcl-2 rs956572 SNP may modulate cognitive function and regional GM volume in non-demented elderly men, and that this polymorphism may affect language performance through its effect on the right MTG.
Full text · PMCdoi:10.1371/journal.pone.0056663
We found that the volume of these five regions decreased with increasing age (all P<.001).
doi:10.3109/07420528.2012.741172
These findings highlight the need for research on identification and management of seasonal features in bipolar patients.
Full text · PMCdoi:10.1186/1471-2334-13-351
Cox regression revealed age and male gender as risk factors for newly-diagnosed TB.
doi:10.1016/j.neulet.2013.09.057
Our data supports that the T allele of IL-1A rs1800587 genetic polymorphism is associated with better cognitive function in the elderly.
doi:10.1016/j.pnpbp.2012.09.015
A defining but elusive feature of the human brain is its astonishing complexity.
Full text · PMCdoi:10.1371/journal.pone.0065072
The ECG-based CPC analysis provides a straightforward means to quantify sleep quality and stability in medical staff performing shift work under stressful conditions.
Full text · PMCdoi:10.1186/1471-230X-13-18
Increased serum AST and abnormal autonomic nervous activities by HRV analysis were associated with psychological distress in cirrhosis.
Case report of a reversible skin rash in a bipolar patient on a first-generation antipsychotic, informing drug-safety monitoring.
doi:10.1212/WNL.0b013e3182a956ad
To evaluate the risk of Parkinson disease (PD) among patients with depression by using the Taiwan National Health Insurance Research Database (NHIRD).
Full text · PMCdoi:10.1371/journal.pone.0078655
The SA patients in this study had a 1.70-times greater risk of developing dementia within 5 years of diagnosis compared to non-SA age- and sex-matched patients, after adjusting for other risk factors (95% confidence interval (CI) = 1.26-2.31; P < .01).
This study investigated the association of suicide deaths with suicide news in longitudinal and spatial dimensions.
Full text · PMCdoi:10.1371/journal.pone.0057066
This study demonstrated the effect of cold temperatures on the COPD exacerbation rate.
Full text · PMCdoi:10.1159/000345980
The findings suggest that the BACE1 rs638405 polymorphism may affect cerebellar morphology, but not cognitive function in healthy humans.
doi:10.1111/j.1601-183X.2011.00741.x
Study findings identified a significant link between the CHRNA4:rs1044396 polymorphism and depression and loneliness in the aged.
doi:10.1016/j.neulet.2012.05.065
Our findings suggest that MTHFR C677T polymorphism may be linked more to loneliness than depression in the cognitively normal elderly males, and may be implicated in the pathophysiology of late-life depression in relation to MTHFR genes.
Results show that a set of suicide-related search terms, the trends of which either temporally coincided or preceded trends of suicide data, were associated with suicide death.
Full text · PMCdoi:10.1371/journal.pone.0018024
Our findings link BDNF Val66Met polymorphism with the severity of RCVS for the first time and implicate possible pathogenic mechanisms for vasoconstriction in RCVS.
Full text · PMCdoi:10.1371/journal.pone.0019232
Our results provide evidence that β(2)-AR polymorphisms are significantly associated with the acceleration/deceleration pattern of heart rate oscillation, reflecting the underlying mode of autonomic nervous system control.
This study comprehensively assesses the temporal relationship between suicide and air pollution, weather, and unemployment variables in Taipei City from January 1 1991 to December 31 2008.
These results suggest that a heterozygote advantage exists for the MTHFR C677T polymorphism in specific cognitive functions in elderly Chinese males without dementia.
Case report showing myasthenic crisis can mimic antipsychotic-induced extrapyramidal syndromes — an important differential-diagnosis caution.
doi:10.1016/j.neulet.2011.08.051
This study replicated these findings in Chinese elderly males without dementia.
These findings could highlight the importance of treating insomnia as an independent disease rather than a symptom.
Full text · PMCdoi:10.1111/j.1469-8986.2010.01060.x
Sleep disruption is an important aspect of major depressive disorder but lacks an objective and inexpensive means of assessment.
Full text · PMCdoi:10.1371/journal.pone.0014612
We found no associations between the raw time series of weather variables and headache incidence.
doi:10.1111/j.1532-5415.2010.03096.x
Population study linking reduced renal function to poorer cognitive performance in community-dwelling elderly men without dementia.
These results suggest that an altered sympathovagal balance with relatively decreased parasympathetic activity is associated with the Met/Met genotype, suggesting a potential role for the studied BDNF polymorphism in modulating cardiac autonomic functions.
Full text · PMCdoi:10.1371/journal.pone.0013728
Our findings indicate that Internet searches for depression from people in higher latitudes are more vulnerable to seasonal change, whereas this phenomenon is obscured in tropical areas.
A review introducing the principles and techniques of heart rate variability (HRV) analysis and illustrating how autonomic nervous system dysregulation, measured by HRV, is associated with psychopathology and cardiovascular comorbidity in psychiatric disorders.
Using a validated electrocardiogram-based cardiopulmonary coupling (CPC) analysis in 155 healthy Taiwanese subjects, this study profiles how age and gender affect sleep-related cardiovascular and respiratory dynamics, establishing normative objective sleep-quality references.
Full text · PMCdoi:10.1371/journal.pone.0007733
A total of 102 robust, non-demented, elderly subjects with normal functions of daily activities participated in this study (97 males and 5 females, aged 79.2+/-4.4 years, range 72-92 years).
doi:10.1111/j.1532-5415.2008.01662.x
Early study associating greater heart-rate-variability complexity with better cognitive function in non-demented elderly men, linking autonomic and brain health.
We recently proposed a novel approach to categorize information carried by symbolic sequences based on their usage of repetitive patterns.
The information based similarity index provides a new tool to measure the similarity between datasets based on their information content and may have a wide range of applications in the large-scale analysis of genomic databases.
Full text · PMCdoi:10.1186/1475-925X-3-39
This study evaluated the effects of stroke on regulation of cerebral blood flow in response to fluctuations in systemic blood pressure (BP).
Reply defending the information-based dissimilarity index for heartbeat dynamics, clarifying that it captures structure beyond conventional mean/variance statistics of heart rate.
doi:10.1016/S0378-4371(03)00622-X
An information-based similarity index, derived from symbolic-dynamics methods used for physiologic signals, is applied to resolve disputed literary authorship by quantifying the statistical structure of texts.
doi:10.1103/PhysRevLett.90.108103
Complex physiologic signals may carry unique dynamical signatures that are related to their underlying mechanisms.
A Markovian model that simulates healthy human heart-rate dynamics by mapping interbeat-interval changes to binary symbols, reproducing short- and long-term fluctuations, circadian rhythm, and heart-rate variability during REM sleep.
A symbolic-dynamics 'footprint' algorithm applied to single-channel ECG to predict the onset of paroxysmal atrial fibrillation, providing a fully automatic prediction tool based on RR-interval mapping.
