Publications
Peer-reviewed work from the laboratory across nine research areas. 212 of 214 link to their DOI.
Psychiatry and clinical neurosciences, 80(3): 215-223
These findings support its potential as an indirect biomarker of neurobiological alterations.
Journal of physiological investigation, 69(2): 118-126
A review mapping how digital medicine — wearables, AI and big data — is reshaping neuropsychiatry and enabling an emerging framework of precision psychiatry.
Pain research & management, 2026: 5504074
HHSA revealed two dominant cross-frequency interactions within the alpha-carrier band (8-16 Hz): one modulated by 3-6-Hz (high-delta to theta) and another by 1-2-Hz (low-delta) oscillations, indicating layered modulation under anesthesia.
European archives of psychiatry and clinical neuroscience
Our findings suggested active cognitive rehabilitation to patients with schizophrenia throughout the course of illness may be warranted.
European heart journal. Digital health, 6(2): 252-260
Cox regression analyses showed that LVH identified by AI algorithm (hazard ratio and 95% confidence interval: 1.587, 1.309-1.924), Sokolow-Lyon (1.19, 1.038-1.365), Cornell product (1.301, 1.124-1.505), Cornell/strain index (1.306, 1.185-1.439), Framingham criterion (1.174, 1.062-1.298), and echocardiography-confirmed LVH (1.124, 1.019-1.239) were all significantly associated with mortality.
Nature communications, 16(1): 3525
Our findings elucidate the complex relationships between IR surrogate markers, genetic predisposition, and disease phenotypes in the Taiwanese population, contributing valuable insights to the field of metabolic research.
Psychiatry and clinical neurosciences, 79(3): 98-107
However, these results do not remain after Bonferroni correction.
Psychological medicine, 55: e253
These findings highlight the potential of brain aging trajectories as biomarkers for BD and MDD, offering insights into distinct and overlapping neuroanatomical changes.
Progress in neuro-psychopharmacology & biological psychiatry, 137: 111270
Following genome-wide association tests, we found genetic variants and SNP-mapped genes and verified the areal preferential expression profiles in the developing human and mouse neocortex.
Brain and behavior, 15(7): e70688
Further, single-cell RNA sequencing and in situ hybridization analyses revealed dynamic expression patterns of the schizophrenia-associated genes during cortical development, suggesting their potential roles in the structural abnormalities observed in schizophrenia.
Biological psychology, 200: 109101
Our findings reveal that active neural interactions or modulations during wakefulness and REM sleep are characterized by super-Gaussian iPDF patterns.
Neuroimage. Reports, 5(1): 100246
MRI analysis revealed significant differences in brain regions, including the posterior cingulate gyrus, lenticular nucleus, olfactory cortex, and cerebellum.
Journal of medical Internet research, 26: e51615
Both models demonstrated adequate at-home screening capabilities for sleep disorders, particularly for patients unsuitable for in-laboratory sleep studies.
Progress in brain research, 290: 141-156
Analysis of pixel value histograms demonstrated varying degrees of similarity, as measured by the Structural Similarity Index (SSIM), between raw and generated features across different facial features.
Alzheimer's research & therapy, 16(1): 88
For the structural randomness, we found significant decreases in the temporal and subcortical areas and significant increases in the occipital and frontal regions.
NeuroImage, 289: 120540
These results underscore the importance of exploring timescales of BOLD signals when constructing FBN and highlight the relevance of specific intrinsic FBNs to aging and cognitive performance.
BMC psychiatry, 24(1): 855
Our findings revealed a noteworthy sex-by-diagnosis interaction, with male individuals with bipolar I disorder displaying larger gray matter volume and altered functional connectivity in the limbic system compared to female individuals with bipolar I disorder and healthy participants.
Journal of the Chinese Medical Association : JCMA, 87(7): 714-721
We found nine core subjects, constituting four different learning pathways.
JMIR formative research, 8: e47803
In conclusion, this study successfully used machine learning methodologies, particularly the LightGBM model, to differentiate SR and AF based on power spectral features derived from 12-lead ECGs.
Pain practice : the official journal of World Institute of Pain, 24(1): 82-90
Accurate predictions of postoperative pain intensity are necessary for customizing analgesia plans.
Psychiatry and clinical neurosciences, 78(1): 69-76
We investigated all suicide cases in 2007-2017 identified from the national cause-of-death data files, with each suicide case matched to 10 controls by age and sex and each suicide case/control assigned to one of the 355 townships across Taiwan.
Journal of the Chinese Medical Association : JCMA, 86(6): 596-605
These preliminary findings suggest that systemic inflammation is not only a complication of OSA but also that it mediates the surgical effects, which may open avenues for potential interventions to reduce tonsil size and OSA severity through the regulation of IL-8 and CCL5.
IEEE journal of biomedical and health informatics, 27(7): 3657-3665
Our findings, by shedding light on the underlying transmission mechanism of infectious diseases, suggest that causal inference analysis is a promising approach to determine epidemiological interventions.
Frontiers in public health, 11: 1160647
This study aimed to investigate the dietary profile of pediatric OSA patients, effects of educational counseling after adenotonsillectomy, and predictor for disease resolution.
Frontiers in psychiatry, 14: 1305359
Pair-wise brain regions with significantly different functional connectivity among the two groups were identified and further analyzed for their concurrent ratio of connectomic differences with another solitary brain region (single-FC dysfunction) or dynamically interconnected brain network (network-FC dysfunction).
Translational psychiatry, 13(1): 82
Our findings provided more insights into schizophrenia neuropathology.
The pharmacogenomics journal, 23(2-3): 50-59
In conclusion, we identified loci that may affect the clinical response to treatment with antidepressants in the context of empirically defined depressive syndromal factors and side effects among the Taiwanese Han population, thus providing novel biological targets for further investigation.
Advanced Intelligent Systems
A multitask deep-learning model performs automated sleep staging and integrates with wearable technology, enabling efficient sleep monitoring outside the traditional polysomnography laboratory.
Psychological medicine, 53(13): 6161-6170
Our findings of high PAF from major depressive disorder, dysthymia, and sleep disorder to youth suicides suggest that youth suicide prevention that focuses on detecting and treating mental illness may usefully target these disorders.
Schizophrenia (Heidelberg, Germany), 9(1): 1
Our findings suggest that schizophrenia differentially affects the decline of different brain structures during the disease course.
Schizophrenia (Heidelberg, Germany), 9(1): 2
Schizophrenia is a chronic brain disorder, and neuroimaging abnormalities have been reported in different stages of the illness for decades.
Journal of pharmaceutical and biomedical analysis, 233: 115456
Our previous study demonstrated a surface-enhanced Raman scattering (SERS)-based approach to identify nicotine-containing e-liquids; without any pre-treatment, e-liquid can be directly tested on our solid-phase SERS substrates, made of silver nanoparticle arrays embedded in anodic aluminium oxide nanochannels (Ag/AAO).
Scientific reports, 13(1): 11231
In conclusion, sleep quality and distinction between wake- and sleep-related autonomic function may be biomarkers for early AD detection.
Journal of psychiatric research, 161: 377-385
Our findings indicated that pre-treatment, right-side cortical hyperactivation is associated with poor outcomes of antidepressant-based or ECT-based treatment in major depression.
Journal of neurology, 270(11): 5536-5544
While our preliminary study suggests that NOTCH3 p.R544C may influence blood pressure, stroke, and dementia in the Taiwan Biobank, replication in a well-powered external sample is required.
Frontiers in public health, 11: 1103085
Multivariable linear regression models in the baseline analysis revealed independent relationships between tonsil size and obstructive apnea-hypopnea index (OAHI), adenoidal-nasopharyngeal ratio and very low frequency (VLF) power of HRV (an indicator of sympathetic activity), and normalized low frequency power (an indicator of sympathetic activity) and OAHI.
Psychosomatic medicine, 84(5): 621-631
Autonomic neural controls in sleep regulation have been previously demonstrated; however, whether these alternations can be observed by different sleep staging approaches remains unclear.
Age and ageing, 51(5)
age-related neurovascular structural and functional impairment is a major aetiology of dementia and stroke in older people.
Journal of personalized medicine, 12(3)
These preliminary findings from the meta-analysis suggest that dCBT-i is a moderately effective treatment in managing insomnia in younger age groups, and CBT-i delivered through the web or a mobile application is an acceptable approach for promoting sleep health in young people.
Frontiers in aging neuroscience, 14: 885090
Results: The homozygous major allele of rs2298813 was associated with larger volumes in the right putamen (p = 0.0442) and right pallidum (p = 0.0346).
Therapeutic advances in neurological disorders, 15: 17562864221138154
These findings can assist clinicians in predicting changes in cognitive status in individuals with a high risk of Alzheimer's disease and can assist future studies in developing precise treatment and prevention strategies.
BMC psychiatry, 22(1): 77
Furthermore, a sex-based subgroup analysis revealed that the risk of hip fracture remained significantly higher in female patients with schizophrenia (HR: 2.68, 95% CI: 1.32-5.44) than in female controls.
Nature communications, 13(1): 2859
Author reply defending empirical-mode-decomposition causal analysis against published critiques, clarifying when it correctly distinguishes causation from shared external forcing.
EClinicalMedicine, 51: 101543
Our results show that the proposed method provides sufficient treatment recommendations that are comparable to those of specialists.
Journal of the Formosan Medical Association = Taiwan yi zhi, 121(10): 2001-2011
Patients with depressive disorders were identified based on International Classification of Diseases codes.
Journal of the Chinese Medical Association : JCMA, 85(5): 633-638
People may experience tinnitus after sudden hearing impairment.
Schizophrenia research, 238: 10-19
These findings suggest that schizophrenia has abnormal brain signal complexity linked to psychotic symptoms.
BMC medical genomics, 14(1): 223
Our results indicate that rs189790076 in GABRA5 and gene-gene interactions among GABRB3, GABRA5, and GABRG3 may contribute to sleep duration in the Taiwanese population.
Aging, 13(14): 18769-18788
Our study suggests that genetic variants in the dopamine receptor-related loci may influence cognitive aging individually and by means of gene-physical activity interactions.
Frontiers in psychiatry, 12: 655292
This study aimed to differentiate between patients with FES and healthy controls (HCs) on basis of the frontotemporal activity measured by NIRS with a support vector machine (SVM) and deep neural network (DNN) classifier.
Frontiers in aging neuroscience, 13: 625931
Our findings show that comparing to gyri, the sulcal thinning is the most prominent pattern during the aging process, and the gyrification of pial and white matter surfaces were also affected differently, which implies the vulnerability of functional segregation during aging.
Psychiatry research, 295: 113518
This study explored morning cardiovascular function in individuals with sleep-onset insomnia by analysing heart rate variability (HRV), blood pressure variability, and baroreflex sensitivity.
Human molecular genetics, 30(23): 2362-2369
From our analysis, we generalize to the Taiwanese population genome-wide significant associations with height and 18 previously identified genes in European and non-Taiwanese East Asian populations.
Frontiers in aging neuroscience, 13: 623930
Conclusion: The present study suggests that EEG power correlates to behavioral and psychological symptoms among patients with mild Alzheimer's disease.
Journal of medical Internet research, 23(9): e24554
We found that fever, gastroenteritis, poison, cruise, wedding, and watery diarrhea were important factors correlated with norovirus Google Trends.
Journal of personalized medicine, 11(7)
Our study suggests that an integrated machine learning and genome-wide analysis approach may offer an advantageous method to establish bioinformatics tools for discriminating MDD patients from healthy controls.
Journal of affective disorders, 281: 872-879
This study aimed to explore whether complexity measures of electroencephalogram (EEG) signals vary across the frontal region between patients with or without remission in depression.
Journal of the American Heart Association, 10(24): e021585
Mediation analysis revealed a significant mediation effect between HRV and GHF in addition to their respective detrimental effects on survival.
Journal of personalized medicine, 11(12)
In emulation of clinical trials, the model-selected regimen was associated with a reduced treatment failure rate.
Diabetes, 69(12): 2819-2829
Except for passive smoking, all smoking measurements were associated with FG, HbA1c, and diabetes (P < 0.0033) and were associated with an exacerbation of the genetic risk of FG and HbA1c (P Interaction < 0.0033).
Psychiatry research, 291: 113257
Research suggests that the aging relates to variability of resting-state fMRI (rs-fMRI) signal and the functional connectivity.
Sleep medicine, 73: 70-75
Our results indicate that the circadian clock gene RORA may contribute to sleep duration independently as well as through gene-gene and gene-environment interactions in the Taiwanese population.
Genes, brain, and behavior, 19(5): e12639
This study provides evidence for the genetic overlap between schizophrenia and tobacco use in women, and this overlap was stronger in the younger population.
Cerebral cortex (New York, N.Y. : 1991), 30(3): 1213-1233
To go beyond the disconnectivity hypothesis of schizophrenia, directed (effective) connectivity was measured between 94 brain regions, to provide evidence on the source of the changes in schizophrenia and a mechanistic model.
Scientific reports, 10(1): 18118
We found that one or two copies of the G allele in rs671 (ALDH2) increased the risk of excessive alcohol consumption, while one or two copies of the C allele in rs3782886 (BRAP) reduced the risk of excessive alcohol consumption.
Frontiers in psychiatry, 11: 531801
Results demonstrated that AD patients had lower complexity on short time scales and higher complexity on long time scales in the alpha band in temporal regions of the brain.
Frontiers in psychiatry, 11: 542394
Discussion: Together, our approach under the EDNN framework demonstrated the potential future direction of making a schizophrenia diagnosis based on structural brain imaging data.
Frontiers in neuroscience, 14: 337
Editorial introducing advances in multi-scale entropy and complexity analysis of brain signals across neuroimaging modalities.
Schizophrenia bulletin, 46(2): 422-431
These findings provide direct evidence for the disconnection hypothesis of schizophrenia, suggesting that abnormalities in the basal ganglia-thalamus-cortex circuit can be used as a biomarker of schizophrenia.
Frontiers in pharmacology, 11: 559601
From two MDD groups in the antidepressant therapeutic response, by using gene-based analyses, we have identified 14 polymorphisms as suggestive markers for therapeutic response (13 for remission and 1 for response) in both meta- and mega-analyses.
Journal of clinical monitoring and computing, 34(6): 1311-1319
For baseline HRV analysis, we found significant differences in the RMSSD (p = 0.043), pNN50 (p = 0.029), VLF power (p = 0.035), LF power (p = 0.004), and HF power (p = 0.037) between the good and poor sleeper groups.
Cerebral cortex (New York, N.Y. : 1991), 30(11): 5844-5862
These findings provide empirical evidence supporting the estimation of brain age from a brain network perspective, and demonstrate the clinical feasibility of evaluating neurological diseases hypothesized to be associated with accelerated brain aging.
Pharmaceuticals (Basel, Switzerland), 13(10)
Our study demonstrates that the ensemble machine learning framework may present a useful technique to create bioinformatics tools for discriminating non-responders from responders prior to antidepressant treatments.
BMC neurology, 20(1): 338
From Taiwan's National Health Insurance Research Database, we identified the data of patients newly diagnosed as having gout between January 1, 2000 and December 1, 2000.
International journal of molecular sciences, 21(6)
Major depressive disorder (MDD), which is a leading psychiatric illness across the world, severely affects quality of life and causes an increased incidence of suicide.
Human molecular genetics, 29(7): 1218-1228
Previous studies have shown that men and women have different genetic architectures across many traits.
Psychiatry research, 293: 113454
Our findings suggest that patients with RLS and PLMS have poorer subjective sleep and mood scales.
Frontiers in psychiatry, 11: 606
The association between tinnitus and anxiety disorder remains debated.
Scientific reports, 10(1): 12134
Our results indicate an association between tinnitus and higher risk of developing AD and PD.
Schizophrenia research, 215: 181-189
These findings suggest a highly individualized pattern of structural dysconnectivity underlies the heterogeneity of schizophrenia, but these disruptions likely converge on an emergent common pathway to generate the clinical phenotype of the disorder.
Biological psychiatry. Cognitive neuroscience and neuroimaging, 5(5): 542-553
These findings suggest that prominent psychiatric disorders share common impairments, possibly linked to perception and motor output, as well as unique dysconnectivity profiles that hypothetically mediate the more distinctive features of the disorder-specific psychopathology.
NeuroImage, 188: 628-641
To demonstrate the utility of sKPCR for real data analysis, we have also compared sKPCR with the above methods based on the identification of voxel-wise differences between schizophrenic patients and healthy controls in four independent rsfMRI datasets.
Frontiers in neurology, 10: 1065
Evidence suggests that the neuro-inflammation mechanisms associated with interleukin-12 (IL-12) may be linked to Alzheimer's diseases and cognitive aging.
CNS spectrums, 24(4): 453-459
Logistic regression analyses with the adjustment of demographic data revealed that the unaffected siblings of patients with schizophrenia were more likely to develop T2DM (odds ratio [OR]: 1.39, 95% confidence interval [CI]: 1.10-1.75) later in life compared with the control group.
PLoS genetics, 15(8): e1008277
Our findings show that the genetic effects on obesity measures can be decreased to various extents by performing different kinds of exercise.
DNA repair, 78: 1-6
Additionally, we found that interactions between the EXO1 and RAD51C genes influenced cognitive aging (P = 0.002).
Frontiers in psychiatry, 10: 481
The chronic autoimmune disease myasthenia gravis (MG) is characterized by fluctuating muscle weakness, which can lead to a large amount of stress in the patient.
ANQ: A Quarterly Journal of Short Articles, Notes and Reviews
A computational stylometric approach is used to test and validate the enlarged canon of works attributed to the Elizabethan playwright Thomas Kyd, applying quantitative text-analysis methods to questions of literary authorship.
Frontiers in psychiatry, 9: 290
By using the SNP dataset that was original to a genome-wide association study, we selected 10 SNPs (including ABCA13 rs4917029, BNIP3 rs9419139, CACNA1E rs704329, EXOC4 rs6978272, GRIN2B rs7954376, LHFPL3 rs4352778, NELL1 rs2139423, NUAK1 rs2956406, PREX1 rs4810894, and SLIT3 rs139863958) which were associated with antidepressant treatment response.
Frontiers in neuroscience, 12: 398
Furthermore, an increased relative error of SampEn was associated with an increased coefficient of variation in voxel-wise statistics.
PloS one, 13(8): e0200682
Patients who experienced a stroke during the follow-up period were identified.
NeuroImage. Clinical, 20: 594-602
We replicated these findings using an automated anatomical labeling atlas to define the network node.
Nature communications, 9(1): 3378
Furthermore, we demonstrate the generic applicability of our method to both stochastic and deterministic systems, and show the consistency of causal-decomposition method compared to existing methods, and finally uncover the key mode of causal interactions in both modelled and actual predator-prey systems.
PloS one, 13(2): e0191202
Our results show that, among these modalities, fMRI has the most significant featureby calculating the Jaccard similarity coefficient (0.7416) and Kappa index (0.4833).
Biological psychiatry. Cognitive neuroscience and neuroimaging, 3(2): 187-197
Moreover, we show how the approach can be used to measure the differences in effective connectivity between different groups of individuals, using as an example effective connectivity in the healthy brain and in individuals with depression.
Neurobiology of aging, 70: 59-69
These findings indicate that resting-state fMRI signal modulations are dynamic during the normal aging process.
Progress in neuro-psychopharmacology & biological psychiatry, 86: 114-121
These results provide further evidence that abnormal variability and lateralization exist in schizophrenia patients, and abnormality in fusiform, lingual and inferior temporal could have potential help to identify the dysfunctional brain lateralization in schizophrenia.
Social cognitive and affective neuroscience, 13(6): 557-568
To analyse the functioning of the amygdala in depression, we performed the first voxel-level resting state functional-connectivity neuroimaging analysis of depression of voxels in the amygdala with all other voxels in the brain, with 336 patients with major depressive disorder and 350 controls.
Scientific reports, 8(1): 6983
For case-control association study, we found that all of these reported polymorphisms and genes did not reach a suggestive level.
Translational psychiatry, 8(1): 90
To analyze the functioning of the posterior cingulate cortex (PCC) in depression, we performed the first fully voxel-level resting state functional-connectivity neuroimaging analysis of depression of the PCC, with 336 patients with major depressive disorder and 350 controls.
Frontiers in neuroscience, 12: 758
Conclusions: The current findings suggest that the desynchronization of the mu wave during MR results in a local increase of mu entropy in sensorimotor areas, potentially reflecting a release from alpha inhibition.
Sleep medicine reviews, 37: 85-93
The analysis of electroencephalography (EEG) recordings has attracted increasing interest in recent decades and provides the pivotal scientific tool for researchers to quantitatively study brain activity during sleep, and has extended our knowledge of the fundamental mechanisms of sleep physiology.
Neurobiology of aging, 67: 99-107
Our findings support that the changes in WMH volume in the healthy population follow a nonlinear pattern with age, especially in PVWMH.
Oncotarget, 9(25): 17533-17542
We identified patients who were diagnosed with bipolar disorder in the Taiwan National Health Insurance Research Database.
The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 63(2): 233-238
Our findings suggested that the public health government and clinicians should pay more attention to the TBI risk among patients with ADHD, and further indicated the importance of the optimal treatment for ADHD.
Early intervention in psychiatry, 12(4): 605-612
Using psychiatric co-morbidities, we identified four variables as significant risk predictors of BPD and permitted identification of subjects with low, intermediate or high risk for BPD.
Behavioral sleep medicine, 16(4): 398-411
This pilot study evaluated the effects of Tai Chi training on sleep quality (primary outcomes), and depression and social functioning levels (secondary outcomes) among patients with depression.
Frontiers in neuroscience, 12: 685
In this study, we aim to discover the altered spatio-temporal patterns of EEG complexity associated with AD pathology in different severity levels.
Oncotarget, 8(15): 24077-24087
Additionally, we found the interactions among CASS4-rs911159, EPHA-rs10952552, FERMT2-rs4901317, MEF2C-rs9293506, or SLC24A4-rs67063100 on cognitive aging (P = 0.004~0.035).
Journal of affective disorders, 215: 269-273
In this study, we used the Taiwan National Health Insurance Research Database (NHIRD) to test the bidirectional association between Bell's palsy and anxiety disorders.
International journal of geriatric psychiatry, 32(5): 556-563
Our findings suggest that depression is an independent risk factor for subsequent VaD.
Oncotarget, 8(55): 93349-93359
Additionally, we found that an interaction between the APOA5 rs662799 and COLEC12 rs16944558 SNPs influenced MetS, high triglyceride, and low HDL.
Oncotarget, 8(15): 24088-24098
In this study, we assessed whether 11 circadian clockgenes are associated with cognitive aging independently and/or through complex interactions in an old Taiwanese population.
PloS one, 12(3): e0173861
Additionally, we found interactions among the ARNTL rs10832020, GSK3B rs2199503, PER3 rs10746473, RORA rs8034880, and RORB rs972902 SNPs influenced MetS (P < 0.001 ~ P = 0.002).
Pain medicine (Malden, Mass.), 18(8): 1557-1565
Malignant neoplasm (hazard ratio = 3.08) and living in urban areas (hazard ratio = 3.05) were identified as independent risk factors for myofascial pain syndrome in patients with insomnia.
Physica A: Statistical Mechanics and its Applications, 468: 783-789
Borrowing concepts from statistical physics, the authors define an information-based 'energy' and 'temperature' of literary texts, providing a thermodynamic-style framework to characterize the complexity and style of written language.
Journal of affective disorders, 216: 89-99
Furthermore, we found significant differences as well as overlaps of pathologic brain signal complexity between psychotic probands by DSM diagnoses, thus suggesting a biological approach to categorizing psychosis based on functional neuroimaging data.
International journal of molecular sciences, 18(8)
Schizophrenia has been primarily associated with dopamine dysfunction, and treatments have been developed that target the dopamine pathway in the central nervous system.
Frontiers of medicine, 11(3): 423-431
This study aimed to evaluate the quality and readability of insomnia-related online information.
Archives of women's mental health, 20(3): 463-468
Cox regression analysis after adjusting for demographic data and psychiatric comorbidities further showed that symptomatic menopausal transition was associated with an increased risk of developing bipolar disorder (HR 1.14, 95% CI 1.07∼1.23) among midlife women with major depression.
PloS one, 12(2): e0172440
Additionally, we found that interactions between the ADAMTS9 rs9985304 and ADAMTS9 rs76346246 SNPs influenced cognitive aging (P < 0.001).
Dementia and geriatric cognitive disorders, 43(3-4): 119-127
However, the 3-marker haplotype derived from the rs1713985, rs3796529, and rs7680734 SNPs in the REST gene demonstrated no association with cognitive aging.
Scientific reports, 7(1): 13589
Our findings indicated that the TGF-β signaling pathway-associated genes of SMAD2 and TGFBR2 may contribute to the risk of MetS independently and through gene-gene interactions.
Scientific reports, 6: 36830
Additionally, we found the interactions of APOA5 rs662799, BUD13 rs11216129, BUD13 rs623908, CETP rs820299, LIPA rs1412444, alcohol consumption, smoking status, or physical activity on MetS and its individual components.
Psychiatry and clinical neurosciences, 70(1): 71
Case report of cyclic Cushing's syndrome presenting with mood instability that mimicked bipolar disorder, highlighting endocrine causes of psychiatric presentations.
Scientific reports, 6: 23362
These findings provide evidence that SORL1 rs3824968 modulates regional GM volume and is associated with brain trajectory during the adult lifespan.
PloS one, 11(1): e0144935
In subgroup analysis, HRV indices demonstrated similar predictive values related to exercise capacity across various subpopulations, especially in the young.
Brain : a journal of neurology, 139(Pt 12): 3296-3309
The first brain-wide voxel-level resting state functional connectivity neuroimaging analysis of depression is reported, with 421 patients with major depressive disorder and 488 control subjects.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 374(2065): 20150206
The Holo-Hilbert spectral analysis (HHSA) method is introduced to cure the deficiencies of traditional spectral analysis and to give a full informational representation of nonlinear and non-stationary data.
The journal of headache and pain, 17(1): 102
Migraine is characterized by a series of phases (inter-ictal, pre-ictal, ictal, and post-ictal).
Journal of affective disorders, 205: 306-310
The importance of mental care for trauma victims would increase in the coming century, and our findings broadened another era for the end result of a widely prevalent psychiatric disorder.
Journal of affective disorders, 197: 94-9
From the National Health Insurance Research Database (NHIRD) in Taiwan, we identified new SSNHL patients diagnosed by an otolaryngologist between January 01, 2000, and December 31, 2008.
Journal of affective disorders, 190: 282-285
Endometriosis was associated with an elevated likelihood of developing depression and anxiety disorders.
The Journal of rheumatology, 43(3): 625-31
We identified subjects who were newly diagnosed with AS between January 1, 2000, and December 31, 2008, in the Taiwan National Health Insurance (NHI) Research Database.
Journal of psychosomatic obstetrics and gynaecology, 37(1): 6-11
Our findings highlight that clinicians should pay particular attention to psychiatric comorbidities in PID patients.
BMC cancer, 16(1): 839
This large nationwide population-based cohort study suggests that there is no increased risk for ovarian, breast or uterine cancer among women who have PID compared to a matching population.
Journal of neuroscience methods, 258: 56-66
We found that EEMD method was efficient to enhance the functional sensitivity of evoked fMRI.
Frontiers in aging neuroscience, 8: 143
These results support the compensatory hypothesis of neurocognitive aging theory and reveal the DTI-fMRI relationship associated with normal aging.
The oncologist, 20(1): 45-9
We identified subjects who were diagnosed with PCOS between January 1, 2000, and December 31, 2004, in the Taiwan National Health Insurance (NHI) Research Database.
Medical science monitor : international medical journal of experimental and clinical research, 21: 100-4
Our findings suggest that loneliness and depression may have negative impacts on global and specific domains of cognitive function in non-demented elderly males.
The journal of pain, 16(9): 895-902
Our results supported a bidirectional temporal association between depression and FMS.
Journal of affective disorders, 176: 171-5
Using Taiwan׳s National Health Insurance Research Database, we identified 500 adolescents and young adults from 2002 to 2008 aged between 15 and 24 years with bipolar disorder and ADHD.
Human brain mapping, 36(6): 2174-86
These results collectively suggested that resting-state dynamics in schizophrenia exhibit two routes of pathologic change toward regular or random patterns, which contribute to the differences in syndrome domains of psychosis in patients with schizophrenia.
Frontiers in aging neuroscience, 7: 251
Loneliness is associated with FCD changes in bilateral lingual gyri that are known to be important in social cognition.
The journal of headache and pain, 16: 533
This diary-based study provides evidence to link the perception of temperature sensitivity and headache incidence in migraine patients.
Sleep medicine, 16(7): 820-6
Furthermore, we found that while studies on drug therapy and adverse effects decreased in the most recent five years, the greatest expansion of insomnia publications were in the areas of cognitive behavioral therapy for insomnia (CBT-I) and alternative therapies.
Journal of affective disorders, 178: 60-5
Subjects who developed major depression, any depressive disorder, and anxiety disorders during the follow-up were identified.
Allergy, 70(12): 1605-12
Those who developed Parkinson's disease during the follow-up period were identified.
European journal of internal medicine, 26(7): 534-9
Recent studies have shown that the peripheral inflammation may cause the up-regulation of central nervous system inflammation and therefore possibly plays a vital role in the pathophysiology of subsequent psychiatric disorders.
PloS one, 10(7): e0133283
Irritable bowel syndrome (IBS) is the most common functional gastrointestinal (GI) disorder observed in patients who visit general practitioners for GI-related complaints.
The Journal of rheumatology, 42(7): 1203-8
Our findings highlight the need for psychiatric evaluation and intervention for patients with pSS.
PloS one, 10(9): e0137914
Patients with late-onset depression (LOD) have been reported to run a higher risk of subsequent dementia.
Neuroscience letters, 576: 17-21
This study suggests that the APOE ɛ4 alleles contributed detrimental effects on cognitive function in the very old veterans who do not have dementia.
PloS one, 9(2): e88749
The effect size (cohen's f) revealed a small effect.
Psychoneuroendocrinology, 39: 94-103
Our findings supported the hypothesis that the BDNF Val66Met polymorphism may affect susceptibility to regional WMH volume and such genotype-by-WMH interaction effect is correlated with cognitive decline in non-demented elderly males, in which the Met allele plays a protective role.
Neuromolecular medicine, 16(1): 127-36
Our findings suggest that the presence of two Met alleles has a protective effect on regional GM volumes in the Chinese population.
Brain structure & function, 219(1): 61-9
Recent resting fMRI studies have suggested that the functional connectivity of the brain's large-scale networks is associated with the cognitive decline of aging and is modulated by genetic factors.
NeuroImage, 102 Pt 2: 894-903
In conclusion, the regional specificity and the stage effect were verified in support of the local awakening concept, indicating that sleep regulation leads to the reorganization of brain networks upon awakening.
Journal of clinical psychopharmacology, 34(2): 276-7
Case report of Pisa syndrome (tonic lateral trunk flexion) emerging after clotiapine discontinuation in a patient with intractable insomnia.
NeuroImage, 90: 218-34
We found that tDCS can further increase the EEG complexity of the frontal lobe.
PloS one, 9(9): e107791
To evaluate the risk of depressive disorders among rheumatoid arthritis (RA) by using the Taiwan National Health Insurance Research Database (NHIRD).
PloS one, 9(5): e97041
We identified patients who were diagnosed with PCOS by an obstetrician-gynecologist in the Taiwan National Health Insurance Research Database.
Sleep medicine, 15(9): 1016-20
Despite not meeting statistical significance, we found increases in the risk of breast cancer in women aged 30-59 years (HR, 2.06; 95% CI, 0.90-4.70) and ≥60 years (HR, 3.05; 95% CI, 0.90-10.32) compared with those aged 0-29 years.
Cephalalgia : an international journal of headache, 34(9): 656-663
Either an increase or a decrease in temperature (0.05℃/day) following a warm period (mean temperature ≥26℃) was associated with the onset of cluster periods.
Human brain mapping, 35(7): 3238-48
These results support the compensatory recruitment hypothesis in older APOE ɛ4 carriers, and confer the impact of the APOE genotype on the temporal dynamics of brain activity in older adults.
Brain and cognition, 92C: 73-83
The results suggest that physical activity may be beneficial for adaptability of brain systems in tasks involving visuo-spatial information.
Cerebellum (London, England), 13(5): 616-22
Our findings suggest that RAB18 rs3765133 polymorphism affects the deve-lopment of specific brain regions, particularly the cerebellum, in healthy people.
Psychiatry research, 210(3): 710-5
These findings may warrant future research in using HRV as objective markers to monitor cardiovascular health and the severity of psychosis in patients with schizophrenia.
International journal of psychiatry in medicine, 45(1): 15-29
Our findings are the first to show that depression and anxiety may be associated with increased levels of CD8 in T-lymphocyte subsets in cirrhosis patients, suggesting that an imbalance of T-lymphocyte subsets may be a factor facilitating depression and anxiety in cirrhotic patients.
The journal of headache and pain, 14(1): 94
This study aimed to assess the autonomic function by analyzing heart rate variability (HRV) in patients with RCVS.
Progress in neuro-psychopharmacology & biological psychiatry, 47: 52-61
MSE analysis revealed abnormal EEG complexity across short- and long-time scales that were correlated to cognitive and neuropsychiatric assessments.
Progress in neuro-psychopharmacology & biological psychiatry, 45: 251-2
Editorial proposing 'complexity' — quantified across behaviour and brain dynamics — as a new research dimension for understanding mental illness.
Neurobiology of aging, 34(2): 428-38
Our findings confirmed the hypothesis that complexity of BOLD activity was correlated with aging and cognitive performance based on MSE analysis, and may provide insights on how dynamics of spontaneous brain activity relates to aging and cognitive function in specific brain regions.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 13(4): 213-20
The aim of this study was to investigate the relationship between social engagement and daytime sleepiness among aged residents of a veterans' housing facility in Taiwan.
PloS one, 8(2): e56663
We found that the volume of these five regions decreased with increasing age (all P<.001).
Age (Dordrecht, Netherlands), 35(2): 343-52
The findings suggest that Bcl-2 rs956572 SNP may modulate cognitive function and regional GM volume in non-demented elderly men, and that this polymorphism may affect language performance through its effect on the right MTG.
Chronobiology international, 30(4): 478-85
These findings highlight the need for research on identification and management of seasonal features in bipolar patients.
BMC infectious diseases, 13: 351
Cox regression revealed age and male gender as risk factors for newly-diagnosed TB.
Neuroscience letters, 556: 69-72
Our data supports that the T allele of IL-1A rs1800587 genetic polymorphism is associated with better cognitive function in the elderly.
Progress in neuro-psychopharmacology & biological psychiatry, 45: 253-7
A defining but elusive feature of the human brain is its astonishing complexity.
PloS one, 8(6): e65072
The ECG-based CPC analysis provides a straightforward means to quantify sleep quality and stability in medical staff performing shift work under stressful conditions.
BMC gastroenterology, 13: 18
Increased serum AST and abnormal autonomic nervous activities by HRV analysis were associated with psychological distress in cirrhosis.
Psychiatry and clinical neurosciences, 67(5): 365
Case report of a reversible skin rash in a bipolar patient on a first-generation antipsychotic, informing drug-safety monitoring.
Neurology, 81(17): 1538-44
To evaluate the risk of Parkinson disease (PD) among patients with depression by using the Taiwan National Health Insurance Research Database (NHIRD).
PloS one, 8(10): e78655
The SA patients in this study had a 1.70-times greater risk of developing dementia within 5 years of diagnosis compared to non-SA age- and sex-matched patients, after adjusting for other risk factors (95% confidence interval (CI) = 1.26-2.31; P < .01).
Social psychiatry and psychiatric epidemiology, 48(3): 427-35
This study investigated the association of suicide deaths with suicide news in longitudinal and spatial dimensions.
PloS one, 8(3): e57066
This study demonstrated the effect of cold temperatures on the COPD exacerbation rate.
Dementia and geriatric cognitive disorders extra, 2(1): 632-7
The findings suggest that the BACE1 rs638405 polymorphism may affect cerebellar morphology, but not cognitive function in healthy humans.
Genes, brain, and behavior, 11(2): 230-4
Study findings identified a significant link between the CHRNA4:rs1044396 polymorphism and depression and loneliness in the aged.
Neuroscience letters, 521(1): 88-91
Our findings suggest that MTHFR C677T polymorphism may be linked more to loneliness than depression in the cognitively normal elderly males, and may be implicated in the pathophysiology of late-life depression in relation to MTHFR genes.
Journal of affective disorders, 132(1-2): 179-84
Results show that a set of suicide-related search terms, the trends of which either temporally coincided or preceded trends of suicide data, were associated with suicide death.
PloS one, 6(3): e18024
Our findings link BDNF Val66Met polymorphism with the severity of RCVS for the first time and implicate possible pathogenic mechanisms for vasoconstriction in RCVS.
PloS one, 6(5): e19232
Our results provide evidence that β(2)-AR polymorphisms are significantly associated with the acceleration/deceleration pattern of heart rate oscillation, reflecting the underlying mode of autonomic nervous system control.
Journal of affective disorders, 129(1-3): 275-81
This study comprehensively assesses the temporal relationship between suicide and air pollution, weather, and unemployment variables in Taipei City from January 1 1991 to December 31 2008.
Dementia and geriatric cognitive disorders, 32(3): 159-63
These results suggest that a heterozygote advantage exists for the MTHFR C677T polymorphism in specific cognitive functions in elderly Chinese males without dementia.
The Journal of neuropsychiatry and clinical neurosciences, 23(2): E36-7
Case report showing myasthenic crisis can mimic antipsychotic-induced extrapyramidal syndromes — an important differential-diagnosis caution.
Neuroscience letters, 504(1): 32-4
This study replicated these findings in Chinese elderly males without dementia.
Journal of affective disorders, 131(1-3): 179-85
These findings could highlight the importance of treating insomnia as an independent disease rather than a symptom.
Psychophysiology, 48(2): 285-91
Sleep disruption is an important aspect of major depressive disorder but lacks an objective and inexpensive means of assessment.
PloS one, 6(1): e14612
We found no associations between the raw time series of weather variables and headache incidence.
Journal of the American Geriatrics Society, 58(10): 2046-8
Population study linking reduced renal function to poorer cognitive performance in community-dwelling elderly men without dementia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 153B(5): 1024-30
These results suggest that an altered sympathovagal balance with relatively decreased parasympathetic activity is associated with the Met/Met genotype, suggesting a potential role for the studied BDNF polymorphism in modulating cardiac autonomic functions.
PloS one, 5(10): e13728
Our findings indicate that Internet searches for depression from people in higher latitudes are more vulnerable to seasonal change, whereas this phenomenon is obscured in tropical areas.
Taiwanese Journal of Psychiatry, 24(2): 99-109
A review introducing the principles and techniques of heart rate variability (HRV) analysis and illustrating how autonomic nervous system dysregulation, measured by HRV, is associated with psychopathology and cardiovascular comorbidity in psychiatric disorders.
Taiwanese Journal of Psychiatry, 24(3): 201-211
Using a validated electrocardiogram-based cardiopulmonary coupling (CPC) analysis in 155 healthy Taiwanese subjects, this study profiles how age and gender affect sleep-related cardiovascular and respiratory dynamics, establishing normative objective sleep-quality references.
PloS one, 4(11): e7733
A total of 102 robust, non-demented, elderly subjects with normal functions of daily activities participated in this study (97 males and 5 females, aged 79.2+/-4.4 years, range 72-92 years).
Journal of the American Geriatrics Society, 56(5): 958-60
Early study associating greater heart-rate-variability complexity with better cognitive function in non-demented elderly men, linking autonomic and brain health.
Chaos (Woodbury, N.Y.), 17(1): 015115
We recently proposed a novel approach to categorize information carried by symbolic sequences based on their usage of repetitive patterns.
Journal of computational biology : a journal of computational molecular cell biology, 12(8): 1103-16
The information based similarity index provides a new tool to measure the similarity between datasets based on their information content and may have a wide range of applications in the large-scale analysis of genomic databases.
Biomedical engineering online, 3(1): 39
This study evaluated the effects of stroke on regulation of cerebral blood flow in response to fluctuations in systemic blood pressure (BP).
Physical Review Letters, 92: 109802
Reply defending the information-based dissimilarity index for heartbeat dynamics, clarifying that it captures structure beyond conventional mean/variance statistics of heart rate.
Physica A: Statistical Mechanics and its Applications, 329(3-4): 473-483
An information-based similarity index, derived from symbolic-dynamics methods used for physiologic signals, is applied to resolve disputed literary authorship by quantifying the statistical structure of texts.
Physical review letters, 90(10): 108103
Complex physiologic signals may carry unique dynamical signatures that are related to their underlying mechanisms.
Computers in Cardiology, 28: 401-404
A symbolic-dynamics 'footprint' algorithm applied to single-channel ECG to predict the onset of paroxysmal atrial fibrillation, providing a fully automatic prediction tool based on RR-interval mapping.
No publications match those filters.