Autonomic Function & Heart Rate Variability

Prediction of early postoperative pain using sleep quality and heart rate variability

Ho CN, Fu PH, Hung KC, Wang LK, Lin YT, … Chen JY (9 authors). Pain practice : the official journal of World Institute of Pain24(1):82-90.

doi:10.1111/papr.13288

Accurate predictions of postoperative pain intensity are necessary for customizing analgesia plans.

Reduced slow-wave activity and autonomic dysfunction during sleep precede cognitive deficits in Alzheimer's disease transgenic mice

Chen CW, Kwok YT, Cheng YT, Huang YS, Kuo TBJ, … Yang CCH (9 authors). Scientific reports13(1):11231.

Full text · PMCdoi:10.1038/s41598-023-38214-6

In conclusion, sleep quality and distinction between wake- and sleep-related autonomic function may be biomarkers for early AD detection.

Using sleep heart rate variability to investigate the sleep quality in children with obstructive sleep apnea

Lee LA, Chuang HH, Hsieh HS, Wang CY, Chuang LP, … Yang CCH (12 authors). Frontiers in public health11:1103085.

Full text · PMCdoi:10.3389/fpubh.2023.1103085

Multivariable linear regression models in the baseline analysis revealed independent relationships between tonsil size and obstructive apnea-hypopnea index (OAHI), adenoidal-nasopharyngeal ratio and very low frequency (VLF) power of HRV (an indicator of sympathetic activity), and normalized low frequency power (an indicator of sympathetic activity) and OAHI.

Associations of Reduced Sympathetic Neural Activity and Elevated Baroreflex Sensitivity With Non-Rapid Eye Movement Sleep: Evidence From Electroencephalogram- and Electrocardiogram-Based Sleep Staging

Tsai HJ, Yang AC, Tsai SJ, Ma Y, Kuo TBJ, … Peng CK (7 authors). Psychosomatic medicine84(5):621-631.

doi:10.1097/PSY.0000000000001079

Autonomic neural controls in sleep regulation have been previously demonstrated; however, whether these alternations can be observed by different sleep staging approaches remains unclear.

Role of Heart Rate Variability in Association Between Glomerular Hyperfiltration and All-Cause Mortality

Chang HC, Huang CJ, Yang AC, Cheng HM, Chuang SY, … Sung SH (9 authors). Journal of the American Heart Association10(24):e021585.

Full text · PMCdoi:10.1161/JAHA.121.021585

Mediation analysis revealed a significant mediation effect between HRV and GHF in addition to their respective detrimental effects on survival.

Heart rate variability and surgical pleth index under anesthesia in poor and normal sleepers

Ho CN, Fu PH, Chen JY, Hung KC, Chang JH, … Yang AC (7 authors). Journal of clinical monitoring and computing34(6):1311-1319.

doi:10.1007/s10877-019-00450-5

For baseline HRV analysis, we found significant differences in the RMSSD (p = 0.043), pNN50 (p = 0.029), VLF power (p = 0.035), LF power (p = 0.004), and HF power (p = 0.037) between the good and poor sleeper groups.

Sleep state instabilities in patients with periodic limb movements in sleep - Detection and quantification with heart rate variability

Lin CY, Tsai SJ, Peng CK, Yang AC. Psychiatry research293:113454.

doi:10.1016/j.psychres.2020.113454

Our findings suggest that patients with RLS and PLMS have poorer subjective sleep and mood scales.

Heart Rate Variability Is Associated with Exercise Capacity in Patients with Cardiac Syndrome X

Lu DY, Yang AC, Cheng HM, Lu TM, Yu WC, … Sung SH (7 authors). PloS one11(1):e0144935.

Full text · PMCdoi:10.1371/journal.pone.0144935

In subgroup analysis, HRV indices demonstrated similar predictive values related to exercise capacity across various subpopulations, especially in the young.

Association of altered cardiac autonomic function with psychopathology and metabolic profiles in schizophrenia

Chung MS, Yang AC, Lin YC, Lin CN, Chang FR, … Chiu HJ (9 authors). Psychiatry research210(3):710-5.

doi:10.1016/j.psychres.2013.07.034

These findings may warrant future research in using HRV as objective markers to monitor cardiovascular health and the severity of psychosis in patients with schizophrenia.

Autonomic dysfunction in reversible cerebral vasoconstriction syndromes

Chen SP, Yang AC, Fuh JL, Wang SJ. The journal of headache and pain14(1):94.

Full text · PMCdoi:10.1186/1129-2377-14-94

This study aimed to assess the autonomic function by analyzing heart rate variability (HRV) in patients with RCVS.

On-call duty effects on sleep-state physiological stability in male medical interns

Lin YH, Ho YC, Lin SH, Yeh YH, Liu CY, … Yang AC (8 authors). PloS one8(6):e65072.

Full text · PMCdoi:10.1371/journal.pone.0065072

The ECG-based CPC analysis provides a straightforward means to quantify sleep quality and stability in medical staff performing shift work under stressful conditions.

Sleep state instabilities in major depressive disorder: Detection and quantification with electrocardiogram-based cardiopulmonary coupling analysis

Yang AC, Yang CH, Hong CJ, Tsai SJ, Kuo CH, … Thomas RJ (9 authors). Psychophysiology48(2):285-91.

Full text · PMCdoi:10.1111/j.1469-8986.2010.01060.x

Sleep disruption is an important aspect of major depressive disorder but lacks an objective and inexpensive means of assessment.

BDNF Val66Met polymorphism alters sympathovagal balance in healthy subjects

Yang AC, Chen TJ, Tsai SJ, Hong CJ, Kuo CH, … Kao KP (7 authors). American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics153B(5):1024-30.

doi:10.1002/ajmg.b.31069

These results suggest that an altered sympathovagal balance with relatively decreased parasympathetic activity is associated with the Met/Met genotype, suggesting a potential role for the studied BDNF polymorphism in modulating cardiac autonomic functions.

Heart rate variability in psychiatric disorders

Yang AC, et al.. Taiwanese Journal of Psychiatry24(2):99-109.

A review introducing the principles and techniques of heart rate variability (HRV) analysis and illustrating how autonomic nervous system dysregulation, measured by HRV, is associated with psychopathology and cardiovascular comorbidity in psychiatric disorders.

Profiling objective sleep quality in a healthy Taiwanese sample using a novel electrocardiogram-based cardiopulmonary coupling analysis

Yang AC, et al.. Taiwanese Journal of Psychiatry24(3):201-211.

Using a validated electrocardiogram-based cardiopulmonary coupling (CPC) analysis in 155 healthy Taiwanese subjects, this study profiles how age and gender affect sleep-related cardiovascular and respiratory dynamics, establishing normative objective sleep-quality references.

Association between heart rate variability and cognitive function in elderly community-dwelling men without dementia: a preliminary report

Yang AC, Tsai SJ, Hong CJ, Yang CH, Hsieh CH, Liu ME. Journal of the American Geriatrics Society56(5):958-60.

doi:10.1111/j.1532-5415.2008.01662.x

Early study associating greater heart-rate-variability complexity with better cognitive function in non-demented elderly men, linking autonomic and brain health.