Digital Medicine in Neuropsychiatry: Prospects, Applications, and the Emerging Framework of Precision Psychiatry

Yang AC

Journal of physiological investigation, 69(2): 118-126 · 2026

A review mapping how digital medicine — wearables, AI and big data — is reshaping neuropsychiatry and enabling an emerging framework of precision psychiatry.

Exploring Nociceptive-Analgesic Balance and EEG Modulation Patterns During General Anesthesia Using Holo-Hilbert Spectral Analysis

Ho CN, Huang NE, Chen JY, Yang AC

Pain research & management, 2026: 5504074 · 2026

HHSA revealed two dominant cross-frequency interactions within the alpha-carrier band (8-16 Hz): one modulated by 3-6-Hz (high-delta to theta) and another by 1-2-Hz (low-delta) oscillations, indicating layered modulation under anesthesia.

Assessing glymphatic function in schizophrenia and mood disorders: Insights from a diffusion tensor image along the perivascular space (DTI-ALPS) and neuroanatomical correlations

Zhu JD, Liao DL, Lin CP, Yang AC, Tsai HJ, Chang HI, Chang CC, Huang CY, Tsai SJ

Psychiatry and clinical neurosciences, 80(3): 215-223 · 2026

These findings support its potential as an indirect biomarker of neurobiological alterations.

Local cortical structure pattern and genetic links in schizophrenia: An MRI and CRISPR/Cas9 study

Hou PS, Lin SF, Zhu JD, Chung CY, Tsai SJ, Yang AC

Progress in neuro-psychopharmacology & biological psychiatry, 137: 111270 · 2025

Following genome-wide association tests, we found genetic variants and SNP-mapped genes and verified the areal preferential expression profiles in the developing human and mouse neocortex.

Identifying key brain pathology in bipolar and unipolar depression using a region-specific brain aging trajectories approach: Insights from the Taiwan Aging and Mental Illness Cohort

Zhu JD, Chi IJ, Hsu HY, Tsai SJ, Yang AC

Psychological medicine, 55: e253 · 2025

These findings highlight the potential of brain aging trajectories as biomarkers for BD and MDD, offering insights into distinct and overlapping neuroanatomical changes.

Cognitive impairment and associated white matter organization abnormalities across the illness course of schizophrenia

Shen CL, Tsai SJ, Lin CP, Yang AC

European archives of psychiatry and clinical neuroscience · 2025

Our findings suggested active cognitive rehabilitation to patients with schizophrenia throughout the course of illness may be warranted.

Unsupervised subtyping of motor dysfunction of Parkinson's disease and its structural brain imaging correlates

Lin YF, Fuh JL, Yang AC

Neuroimage. Reports, 5(1): 100246 · 2025

MRI analysis revealed significant differences in brain regions, including the posterior cingulate gyrus, lenticular nucleus, olfactory cortex, and cerebellum.

Identifying Distinct Developmental Patterns of Brain Complexity in Autism: A Cross-Sectional Cohort Analysis Using the Autism Brain Imaging Data Exchange

Chi IJ, Tsai SJ, Chen CH, Yang AC

Psychiatry and clinical neurosciences, 79(3): 98-107 · 2025

However, these results do not remain after Bonferroni correction.

Gene clusters linked to insulin resistance identified in a genome-wide study of the Taiwan Biobank population

Lin E, Yan YT, Chen MH, Yang AC, Kuo PH, Tsai SJ

Nature communications, 16(1): 3525 · 2025

Our findings elucidate the complex relationships between IR surrogate markers, genetic predisposition, and disease phenotypes in the Taiwanese population, contributing valuable insights to the field of metabolic research.

Quantifying consciousness through intrinsic probability density function

Huang NE, Yuan WS, Yang AC, Kuo TBJ, Tang WX, Kang H, Wagner M, Liang WK

Biological psychology, 200: 109101 · 2025

Our findings reveal that active neural interactions or modulations during wakefulness and REM sleep are characterized by super-Gaussian iPDF patterns.

Mapping Genetic Associations With Functional Brain Area Alterations in Schizophrenia and Implications for Cortical Development

Zhu JD, Chung CY, Lin SF, Tsai SJ, Yang AC, Hou PS

Brain and behavior, 15(7): e70688 · 2025

Further, single-cell RNA sequencing and in situ hybridization analyses revealed dynamic expression patterns of the schizophrenia-associated genes during cortical development, suggesting their potential roles in the structural abnormalities observed in schizophrenia.

Comparison of machine learning and conventional criteria in detecting left ventricular hypertrophy and prognosis with electrocardiography

Huang JT, Tseng CH, Huang WM, Yu WC, Cheng HM, Chao HL, Chiang CE, Chen CH, Yang AC, Sung SH

European heart journal. Digital health, 6(2): 252-260 · 2025

Cox regression analyses showed that LVH identified by AI algorithm (hazard ratio and 95% confidence interval: 1.587, 1.309-1.924), Sokolow-Lyon (1.19, 1.038-1.365), Cornell product (1.301, 1.124-1.505), Cornell/strain index (1.306, 1.185-1.439), Framingham criterion (1.174, 1.062-1.298), and echocardiography-confirmed LVH (1.124, 1.019-1.239) were all significantly associated with mortality.

Exploring morphological similarity and randomness in Alzheimer's disease using adjacent grey matter voxel-based structural analysis

Chen TY, Zhu JD, Tsai SJ, Yang AC

Alzheimer's research & therapy, 16(1): 88 · 2024

For the structural randomness, we found significant decreases in the temporal and subcortical areas and significant increases in the occipital and frontal regions.

Efficient Screening in Obstructive Sleep Apnea Using Sequential Machine Learning Models, Questionnaires, and Pulse Oximetry Signals: Mixed Methods Study

Kuo NY, Tsai HJ, Tsai SJ, Yang AC

Journal of medical Internet research, 26: e51615 · 2024

Both models demonstrated adequate at-home screening capabilities for sleep disorders, particularly for patients unsuitable for in-laboratory sleep studies.

Exploring timescale-specific functional brain networks and their associations with aging and cognitive performance in a healthy cohort without dementia

Tsai WX, Tsai SJ, Lin CP, Huang NE, Yang AC

NeuroImage, 289: 120540 · 2024

These results underscore the importance of exploring timescales of BOLD signals when constructing FBN and highlight the relevance of specific intrinsic FBNs to aging and cognitive performance.

Investigating sex-related differences in brain structure and function in bipolar I disorder using multimodal MRI

Lee MY, Zhu JD, Tsai HJ, Tsai SJ, Yang AC

BMC psychiatry, 24(1): 855 · 2024

Our findings revealed a noteworthy sex-by-diagnosis interaction, with male individuals with bipolar I disorder displaying larger gray matter volume and altered functional connectivity in the limbic system compared to female individuals with bipolar I disorder and healthy participants.

Optimization of Using Multiple Machine Learning Approaches in Atrial Fibrillation Detection Based on a Large-Scale Data Set of 12-Lead Electrocardiograms: Cross-Sectional Study

Chuang BB, Yang AC

JMIR formative research, 8: e47803 · 2024

In conclusion, this study successfully used machine learning methodologies, particularly the LightGBM model, to differentiate SR and AF based on power spectral features derived from 12-lead ECGs.

Enhancing facial feature de-identification in multiframe brain images: A generative adversarial network approach

Lien CY, Deng RJ, Fuh JL, Ting YN, Yang AC

Progress in brain research, 290: 141-156 · 2024

Analysis of pixel value histograms demonstrated varying degrees of similarity, as measured by the Structural Similarity Index (SSIM), between raw and generated features across different facial features.

Learning pathways composed of core subjects with features of reducing cognitive load have better learning outcomes

Huang SS, Huang AY, Lin YF, Lin SM, Webster CS, Lin JY, Yang YY, Yang SJH, Lirng JF, Chen CH, Yang AC, Lin CH

Journal of the Chinese Medical Association : JCMA, 87(7): 714-721 · 2024

We found nine core subjects, constituting four different learning pathways.

Prediction of early postoperative pain using sleep quality and heart rate variability

Ho CN, Fu PH, Hung KC, Wang LK, Lin YT, Yang AC, Ho CH, Chang JH, Chen JY

Pain practice : the official journal of World Institute of Pain, 24(1): 82-90 · 2024

Accurate predictions of postoperative pain intensity are necessary for customizing analgesia plans.

Psychiatrist density and risk of suicide: a multilevel case-control study based on a national sample in Taiwan

Huang WC, Hsu CY, Chang CM, Yang AC, Liao SC, Chang SS, Wu CS

Psychiatry and clinical neurosciences, 78(1): 69-76 · 2024

We investigated all suicide cases in 2007-2017 identified from the national cause-of-death data files, with each suicide case matched to 10 controls by age and sex and each suicide case/control assigned to one of the 355 townships across Taiwan.

Investigating brain aging trajectory deviations in different brain regions of individuals with schizophrenia using multimodal magnetic resonance imaging and brain-age prediction: a multicenter study

Zhu JD, Wu YF, Tsai SJ, Lin CP, Yang AC

Translational psychiatry, 13(1): 82 · 2023

Our findings provided more insights into schizophrenia neuropathology.

Exploring the role of hub and network dysfunction in brain connectomes of schizophrenia using functional magnetic resonance imaging

Chan YE, Tsai SJ, Chern Y, Yang AC

Frontiers in psychiatry, 14: 1305359 · 2023

Pair-wise brain regions with significantly different functional connectivity among the two groups were identified and further analyzed for their concurrent ratio of connectomic differences with another solitary brain region (single-FC dysfunction) or dynamically interconnected brain network (network-FC dysfunction).

Causality Network of Infectious Disease Revealed With Causal Decomposition

Sun J, Yuan K, Chen C, Xu H, Wang H, Zhi Y, Peng S, Peng CK, Huang N, Huang G, Yang A

IEEE journal of biomedical and health informatics, 27(7): 3657-3665 · 2023

Our findings, by shedding light on the underlying transmission mechanism of infectious diseases, suggest that causal inference analysis is a promising approach to determine epidemiological interventions.

Right-side frontal-central cortical hyperactivation before the treatment predicts outcomes of antidepressant and electroconvulsive therapy responsivity in major depressive disorder

Tsai HJ, Yang WC, Tsai SJ, Lin CH, Yang AC

Journal of psychiatric research, 161: 377-385 · 2023

Our findings indicated that pre-treatment, right-side cortical hyperactivation is associated with poor outcomes of antidepressant-based or ECT-based treatment in major depression.

Progressive brain abnormalities in schizophrenia across different illness periods: a structural and functional MRI study

Shen CL, Tsai SJ, Lin CP, Yang AC

Schizophrenia (Heidelberg, Germany), 9(1): 2 · 2023

Schizophrenia is a chronic brain disorder, and neuroimaging abnormalities have been reported in different stages of the illness for decades.

Predicting aging trajectories of decline in brain volume, cortical thickness and fractional anisotropy in schizophrenia

Zhu JD, Tsai SJ, Lin CP, Lee YJ, Yang AC

Schizophrenia (Heidelberg, Germany), 9(1): 1 · 2023

Our findings suggest that schizophrenia differentially affects the decline of different brain structures during the disease course.

The cysteine-altering p.R544C variant in the NOTCH3 gene is a probable candidate for blood pressure and relevant traits in the Taiwan Biobank

Lin E, Kuo PH, Liu YL, Wang TJ, Yang AC, Tsai SJ

Journal of neurology, 270(11): 5536-5544 · 2023

While our preliminary study suggests that NOTCH3 p.R544C may influence blood pressure, stroke, and dementia in the Taiwan Biobank, replication in a well-powered external sample is required.

Population-attributable risk of psychiatric disorders for suicide among adolescents and young adults in Taiwan

Hung YA, Liao SC, Chang CM, Chang SS, Yang AC, Chien YL, Wu CS, Gau SS

Psychological medicine, 53(13): 6161-6170 · 2023

Our findings of high PAF from major depressive disorder, dysthymia, and sleep disorder to youth suicides suggest that youth suicide prevention that focuses on detecting and treating mental illness may usefully target these disorders.

Multitask Learning for Automated Sleep Staging and Wearable Technology Integration

Chih HY, Ahmed T, Chiu AP, Liu YT, Kuo HF, Yang AC, Lien DH

Advanced Intelligent Systems · 2023

A multitask deep-learning model performs automated sleep staging and integrates with wearable technology, enabling efficient sleep monitoring outside the traditional polysomnography laboratory.

Dietary profile of pediatric obstructive sleep apnea patients, effects of routine educational counseling, and predictors for outcomes

Chuang HH, Lin RH, Hsu JF, Chuang LP, Li HY, Fang TJ, Huang YS, Yang AC, Lee GS, Kuo TBJ, Yang CCH, Lee LA

Frontiers in public health, 11: 1160647 · 2023

This study aimed to investigate the dietary profile of pediatric OSA patients, effects of educational counseling after adenotonsillectomy, and predictor for disease resolution.

Using sleep heart rate variability to investigate the sleep quality in children with obstructive sleep apnea

Lee LA, Chuang HH, Hsieh HS, Wang CY, Chuang LP, Li HY, Fang TJ, Huang YS, Lee GS, Yang AC, Kuo TBJ, Yang CCH

Frontiers in public health, 11: 1103085 · 2023

Multivariable linear regression models in the baseline analysis revealed independent relationships between tonsil size and obstructive apnea-hypopnea index (OAHI), adenoidal-nasopharyngeal ratio and very low frequency (VLF) power of HRV (an indicator of sympathetic activity), and normalized low frequency power (an indicator of sympathetic activity) and OAHI.

Adenotonsillectomy-related changes in systemic inflammation among children with obstructive sleep apnea

Huang CG, Hsu JF, Chuang LP, Li HY, Fang TJ, Huang YS, Yang AC, Lee GS, Kuo TBJ, Yang CCH, Lee LA, Chuang HH

Journal of the Chinese Medical Association : JCMA, 86(6): 596-605 · 2023

These preliminary findings suggest that systemic inflammation is not only a complication of OSA but also that it mediates the surgical effects, which may open avenues for potential interventions to reduce tonsil size and OSA severity through the regulation of IL-8 and CCL5.

Rapid detection of nicotine and benzoic acid in e-liquids with surface-enhanced Raman scattering and artificial intelligence-assisted spectrum interpretation

Chien JY, Gu YC, Liu CH, Tsai HM, Lee CN, Yang AC, Huang J, Wang YL, Wang JK, Lin CH

Journal of pharmaceutical and biomedical analysis, 233: 115456 · 2023

Our previous study demonstrated a surface-enhanced Raman scattering (SERS)-based approach to identify nicotine-containing e-liquids; without any pre-treatment, e-liquid can be directly tested on our solid-phase SERS substrates, made of silver nanoparticle arrays embedded in anodic aluminium oxide nanochannels (Ag/AAO).

Investigating genetic variants for treatment response to selective serotonin reuptake inhibitors in syndromal factors and side effects among patients with depression in Taiwanese Han population

Huang SS, Chen YT, Su MH, Tsai SJ, Chen HH, Yang AC, Liu YL, Kuo PH

The pharmacogenomics journal, 23(2-3): 50-59 · 2023

In conclusion, we identified loci that may affect the clinical response to treatment with antidepressants in the context of empirically defined depressive syndromal factors and side effects among the Taiwanese Han population, thus providing novel biological targets for further investigation.

Reduced slow-wave activity and autonomic dysfunction during sleep precede cognitive deficits in Alzheimer's disease transgenic mice

Chen CW, Kwok YT, Cheng YT, Huang YS, Kuo TBJ, Wu CH, Du PJ, Yang AC, Yang CCH

Scientific reports, 13(1): 11231 · 2023

In conclusion, sleep quality and distinction between wake- and sleep-related autonomic function may be biomarkers for early AD detection.

Reply To: Comments on identifying causal relationships in nonlinear dynamical systems via empirical mode decomposition

Yang AC, Peng CK, Huang NE

Nature communications, 13(1): 2859 · 2022

Author reply defending empirical-mode-decomposition causal analysis against published critiques, clarifying when it correctly distinguishes causation from shared external forcing.

Functional MRI and ApoE4 genotype for predicting cognitive decline in amyloid-positive individuals

Zhu JD, Huang CW, Chang HI, Tsai SJ, Huang SH, Hsu SW, Lee CC, Chen HJ, Chang CC, Yang AC

Therapeutic advances in neurological disorders, 15: 17562864221138154 · 2022

These findings can assist clinicians in predicting changes in cognitive status in individuals with a high risk of Alzheimer's disease and can assist future studies in developing precise treatment and prevention strategies.

Brain white matter hyperintensities-predicted age reflects neurovascular health in middle-to-old aged subjects

Huang CC, Chou KH, Lee WJ, Yang AC, Tsai SJ, Chen LK, Chung CP, Lin CP

Age and ageing, 51(5) · 2022

age-related neurovascular structural and functional impairment is a major aetiology of dementia and stroke in older people.

Smartphone-based artificial intelligence using a transfer learning algorithm for the detection and diagnosis of middle ear diseases: A retrospective deep learning study

Chen YC, Chu YC, Huang CY, Lee YT, Lee WY, Hsu CY, Yang AC, Liao WH, Cheng YF

EClinicalMedicine, 51: 101543 · 2022

Our results show that the proposed method provides sufficient treatment recommendations that are comparable to those of specialists.

Hip, vertebral, and wrist fracture risks and schizophrenia: a nationwide longitudinal study

Chu YW, Chen WP, Yang AC, Tsai SJ, Hu LY, Lee SC, Lee YT, Shen CC

BMC psychiatry, 22(1): 77 · 2022

Furthermore, a sex-based subgroup analysis revealed that the risk of hip fracture remained significantly higher in female patients with schizophrenia (HR: 2.68, 95% CI: 1.32-5.44) than in female controls.

Endophenotypic effects of the SORL1 variant rs2298813 on regional brain volume in patients with late-onset Alzheimer's disease

Chen CY, Lin YS, Lee WJ, Liao YC, Kuo YS, Yang AC, Fuh JL

Frontiers in aging neuroscience, 14: 885090 · 2022

Results: The homozygous major allele of rs2298813 was associated with larger volumes in the right putamen (p = 0.0442) and right pallidum (p = 0.0346).

The moderating effect of personality traits on acute tinnitus sensation in idiopathic sudden sensorineural hearing loss

Huang CY, Cheng YF, Yang AC, Lin CJ, Ieong PI, Hsueh CY

Journal of the Chinese Medical Association : JCMA, 85(5): 633-638 · 2022

People may experience tinnitus after sudden hearing impairment.

Ten-year trends in depression care in Taiwan

Wang HH, Chang CM, Chang SS, Yang AC, Liu YH, Liao SC, Wu CS

Journal of the Formosan Medical Association = Taiwan yi zhi, 121(10): 2001-2011 · 2022

Patients with depressive disorders were identified based on International Classification of Diseases codes.

Effectiveness of Digital Cognitive Behavioral Therapy for Insomnia in Young People: Preliminary Findings from Systematic Review and Meta-Analysis

Tsai HJ, Yang AC, Zhu JD, Hsu YY, Hsu TF, Tsai SJ

Journal of personalized medicine, 12(3) · 2022

These preliminary findings from the meta-analysis suggest that dCBT-i is a moderately effective treatment in managing insomnia in younger age groups, and CBT-i delivered through the web or a mobile application is an acceptable approach for promoting sleep health in young people.

Associations of Reduced Sympathetic Neural Activity and Elevated Baroreflex Sensitivity With Non-Rapid Eye Movement Sleep: Evidence From Electroencephalogram- and Electrocardiogram-Based Sleep Staging

Tsai HJ, Yang AC, Tsai SJ, Ma Y, Kuo TBJ, Yang CCH, Peng CK

Psychosomatic medicine, 84(5): 621-631 · 2022

Autonomic neural controls in sleep regulation have been previously demonstrated; however, whether these alternations can be observed by different sleep staging approaches remains unclear.

Predicting Norovirus in the United States Using Google Trends: Infodemiology Study

Yuan K, Huang G, Wang L, Wang T, Liu W, Jiang H, Yang AC

Journal of medical Internet research, 23(9): e24554 · 2021

We found that fever, gastroenteritis, poison, cruise, wedding, and watery diarrhea were important factors correlated with norovirus Google Trends.

Phenotyping Neuropsychiatric Symptoms Profiles of Alzheimer's Disease Using Cluster Analysis on EEG Power

Liu F, Fuh JL, Peng CK, Yang AC

Frontiers in aging neuroscience, 13: 623930 · 2021

Conclusion: The present study suggests that EEG power correlates to behavioral and psychological symptoms among patients with mild Alzheimer's disease.

Remission of depression is associated with asymmetric hemispheric variation in EEG complexity before antidepressant treatment

Tsai HJ, Yang WC, Tsai SJ, Lin CH, Yang AC

Journal of affective disorders, 281: 872-879 · 2021

This study aimed to explore whether complexity measures of electroencephalogram (EEG) signals vary across the frontal region between patients with or without remission in depression.

Alteration of power law scaling of spontaneous brain activity in schizophrenia

Lee YJ, Huang SY, Lin CP, Tsai SJ, Yang AC

Schizophrenia research, 238: 10-19 · 2021

These findings suggest that schizophrenia has abnormal brain signal complexity linked to psychotic symptoms.

Genome-wide association study in the Taiwan Biobank identifies four novel genes for human height: NABP2, RASA2, RNF41 and SLC39A5

Lin E, Tsai SJ, Kuo PH, Liu YL, Yang AC, Conomos MP, Thornton TA

Human molecular genetics, 30(23): 2362-2369 · 2021

From our analysis, we generalize to the Taiwanese population genome-wide significant associations with height and 18 previously identified genes in European and non-Taiwanese East Asian populations.

Role of Heart Rate Variability in Association Between Glomerular Hyperfiltration and All-Cause Mortality

Chang HC, Huang CJ, Yang AC, Cheng HM, Chuang SY, Yu WC, Chiang CE, Chen CH, Sung SH

Journal of the American Heart Association, 10(24): e021585 · 2021

Mediation analysis revealed a significant mediation effect between HRV and GHF in addition to their respective detrimental effects on survival.

An association study in the Taiwan Biobank elicits three novel candidates for cognitive aging in old adults: NCAM1, TTC12 and ZBTB20

Lin E, Kuo PH, Lin WY, Liu YL, Yang AC, Tsai SJ

Aging, 13(14): 18769-18788 · 2021

Our study suggests that genetic variants in the dopamine receptor-related loci may influence cognitive aging individually and by means of gene-physical activity interactions.

An association study in the Taiwan Biobank elicits the GABAA receptor genes GABRB3, GABRA5, and GABRG3 as candidate loci for sleep duration in the Taiwanese population

Hou SJ, Tsai SJ, Kuo PH, Lin WY, Liu YL, Yang AC, Lin E, Lan TH

BMC medical genomics, 14(1): 223 · 2021

Our results indicate that rs189790076 in GABRA5 and gene-gene interactions among GABRB3, GABRA5, and GABRG3 may contribute to sleep duration in the Taiwanese population.

Differential Patterns of Gyral and Sulcal Morphological Changes During Normal Aging Process

Lin HY, Huang CC, Chou KH, Yang AC, Lo CZ, Tsai SJ, Lin CP

Frontiers in aging neuroscience, 13: 625931 · 2021

Our findings show that comparing to gyri, the sulcal thinning is the most prominent pattern during the aging process, and the gyrification of pial and white matter surfaces were also affected differently, which implies the vulnerability of functional segregation during aging.

Deep Neural Network to Differentiate Brain Activity Between Patients With First-Episode Schizophrenia and Healthy Individuals: A Multi-Channel Near Infrared Spectroscopy Study

Chou PH, Yao YH, Zheng RX, Liou YL, Liu TT, Lane HY, Yang AC, Wang SC

Frontiers in psychiatry, 12: 655292 · 2021

This study aimed to differentiate between patients with FES and healthy controls (HCs) on basis of the frontotemporal activity measured by NIRS with a support vector machine (SVM) and deep neural network (DNN) classifier.

Validation of Machine Learning-Based Individualized Treatment for Depressive Disorder Using Target Trial Emulation

Wu CS, Yang AC, Chang SS, Chang CM, Liu YH, Liao SC, Tsai HJ

Journal of personalized medicine, 11(12) · 2021

In emulation of clinical trials, the model-selected regimen was associated with a reduced treatment failure rate.

Prediction of Probable Major Depressive Disorder in the Taiwan Biobank: An Integrated Machine Learning and Genome-Wide Analysis Approach

Lin E, Kuo PH, Lin WY, Liu YL, Yang AC, Tsai SJ

Journal of personalized medicine, 11(7) · 2021

Our study suggests that an integrated machine learning and genome-wide analysis approach may offer an advantageous method to establish bioinformatics tools for discriminating MDD patients from healthy controls.

Difficulty in initiating sleep is associated with poor morning cardiovascular function

Tsai HJ, Kuo TBJ, Yang AC, Tsai SJ, Yang CCH

Psychiatry research, 295: 113518 · 2021

This study explored morning cardiovascular function in individuals with sleep-onset insomnia by analysing heart rate variability (HRV), blood pressure variability, and baroreflex sensitivity.

Editorial: Advances in Multi-Scale Analysis of Brain Complexity

Yang AC, Jann K, Michel CM, Wang DJJ

Frontiers in neuroscience, 14: 337 · 2020

Editorial introducing advances in multi-scale entropy and complexity analysis of brain signals across neuroimaging modalities.

Development of an Al-Based Web Diagnostic System for Phenotyping Psychiatric Disorders

Chang YW, Tsai SJ, Wu YF, Yang AC

Frontiers in psychiatry, 11: 542394 · 2020

Discussion: Together, our approach under the EDNN framework demonstrated the potential future direction of making a schizophrenia diagnosis based on structural brain imaging data.

Heart rate variability and surgical pleth index under anesthesia in poor and normal sleepers

Ho CN, Fu PH, Chen JY, Hung KC, Chang JH, Peng CK, Yang AC

Journal of clinical monitoring and computing, 34(6): 1311-1319 · 2020

For baseline HRV analysis, we found significant differences in the RMSSD (p = 0.043), pNN50 (p = 0.029), VLF power (p = 0.035), LF power (p = 0.004), and HF power (p = 0.037) between the good and poor sleeper groups.

Sleep state instabilities in patients with periodic limb movements in sleep - Detection and quantification with heart rate variability

Lin CY, Tsai SJ, Peng CK, Yang AC

Psychiatry research, 293: 113454 · 2020

Our findings suggest that patients with RLS and PLMS have poorer subjective sleep and mood scales.

Age-related changes in the association of resting-state fMRI signal variability and global functional connectivity in non-demented healthy people

Xie W, Peng CK, Shen J, Lin CP, Tsai SJ, Wang S, Chu Q, Yang AC

Psychiatry research, 291: 113257 · 2020

Research suggests that the aging relates to variability of resting-state fMRI (rs-fMRI) signal and the functional connectivity.

Transdiagnostic and Illness-Specific Functional Dysconnectivity Across Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

Huang CC, Luo Q, Palaniyappan L, Yang AC, Hung CC, Chou KH, Zac Lo CY, Liu MN, Tsai SJ, Barch DM, Feng J, Lin CP, Robbins TW

Biological psychiatry. Cognitive neuroscience and neuroimaging, 5(5): 542-553 · 2020

These findings suggest that prominent psychiatric disorders share common impairments, possibly linked to perception and motor output, as well as unique dysconnectivity profiles that hypothetically mediate the more distinctive features of the disorder-specific psychopathology.

Large-Scale Structural Covariance Networks Predict Age in Middle-to-Late Adulthood: A Novel Brain Aging Biomarker

Kuo CY, Lee PL, Hung SC, Liu LK, Lee WJ, Chung CP, Yang AC, Tsai SJ, Wang PN, Chen LK, Chou KH, Lin CP

Cerebral cortex (New York, N.Y. : 1991), 30(11): 5844-5862 · 2020

These findings provide empirical evidence supporting the estimation of brain age from a brain network perspective, and demonstrate the clinical feasibility of evaluating neurological diseases hypothesized to be associated with accelerated brain aging.

Beyond the disconnectivity hypothesis of schizophrenia

Rolls ET, Cheng W, Gilson M, Gong W, Deco G, Lo CZ, Yang AC, Tsai SJ, Liu ME, Lin CP, Feng J

Cerebral cortex (New York, N.Y. : 1991), 30(3): 1213-1233 · 2020

To go beyond the disconnectivity hypothesis of schizophrenia, directed (effective) connectivity was measured between 94 brain regions, to provide evidence on the source of the changes in schizophrenia and a mechanistic model.

Active Cigarette Smoking Is Associated With an Exacerbation of Genetic Susceptibility to Diabetes

Lin WY, Liu YL, Yang AC, Tsai SJ, Kuo PH

Diabetes, 69(12): 2819-2829 · 2020

Except for passive smoking, all smoking measurements were associated with FG, HbA1c, and diabetes (P < 0.0033) and were associated with an exacerbation of the genetic risk of FG and HbA1c (P Interaction < 0.0033).

Sex-specific autosomal genetic effects across 26 human complex traits

Lin WY, Chan CC, Liu YL, Yang AC, Tsai SJ, Kuo PH

Human molecular genetics, 29(7): 1218-1228 · 2020

Previous studies have shown that men and women have different genetic architectures across many traits.

Functional, Anatomical, and Morphological Networks Highlight the Role of Basal Ganglia-Thalamus-Cortex Circuits in Schizophrenia

Zhao W, Guo S, Linli Z, Yang AC, Lin CP, Tsai SJ

Schizophrenia bulletin, 46(2): 422-431 · 2020

These findings provide direct evidence for the disconnection hypothesis of schizophrenia, suggesting that abnormalities in the basal ganglia-thalamus-cortex circuit can be used as a biomarker of schizophrenia.

Risk of Parkinson's disease following gout: a population-based retrospective cohort study in Taiwan

Hu LY, Yang AC, Lee SC, You ZH, Tsai SJ, Hu CK, Shen CC

BMC neurology, 20(1): 338 · 2020

From Taiwan's National Health Insurance Research Database, we identified the data of patients newly diagnosed as having gout between January 1, 2000 and December 1, 2000.

Gene-Based Association Analysis Suggests Association of HTR2A With Antidepressant Treatment Response in Depressed Patients

Kao CF, Kuo PH, Yu YW, Yang AC, Lin E, Liu YL, Tsai SJ

Frontiers in pharmacology, 11: 559601 · 2020

From two MDD groups in the antidepressant therapeutic response, by using gene-based analyses, we have identified 14 polymorphisms as suggestive markers for therapeutic response (13 for remission and 1 for response) in both meta- and mega-analyses.

Decomposed Temporal Complexity Analysis of Neural Oscillations and Machine Learning Applied to Alzheimer's Disease Diagnosis

Furutani N, Nariya Y, Takahashi T, Noto S, Yang AC, Hirosawa T, Kameya M, Minabe Y, Kikuchi M

Frontiers in psychiatry, 11: 531801 · 2020

Results demonstrated that AD patients had lower complexity on short time scales and higher complexity on long time scales in the alpha band in temporal regions of the brain.

Tinnitus Among Patients With Anxiety Disorder: A Nationwide Longitudinal Study

Hou SJ, Yang AC, Tsai SJ, Shen CC, Lan TH

Frontiers in psychiatry, 11: 606 · 2020

The association between tinnitus and anxiety disorder remains debated.

Association between polygenic liability for schizophrenia and substance involvement: A nationwide population-based study in Taiwan

Wang SH, Lai RY, Lee YC, Su MH, Chen CY, Hsiao PC, Yang AC, Liu YL, Tsai SJ, Kuo PH

Genes, brain, and behavior, 19(5): e12639 · 2020

This study provides evidence for the genetic overlap between schizophrenia and tobacco use in women, and this overlap was stronger in the younger population.

Role of Interleukin-6 in Depressive Disorder

Ting EY, Yang AC, Tsai SJ

International journal of molecular sciences, 21(6) · 2020

Major depressive disorder (MDD), which is a leading psychiatric illness across the world, severely affects quality of life and causes an increased incidence of suicide.

Prediction of Antidepressant Treatment Response and Remission Using an Ensemble Machine Learning Framework

Lin E, Kuo PH, Liu YL, Yu YW, Yang AC, Tsai SJ

Pharmaceuticals (Basel, Switzerland), 13(10) · 2020

Our study demonstrates that the ensemble machine learning framework may present a useful technique to create bioinformatics tools for discriminating non-responders from responders prior to antidepressant treatments.

Topographic diversity of structural connectivity in schizophrenia

Ruan H, Luo Q, Palaniyappan L, Lu W, Huang CC, Zac Lo CY, Yang AC, Liu ME, Tsai SJ, Lin CP, Feng J

Schizophrenia research, 215: 181-189 · 2020

These findings suggest a highly individualized pattern of structural dysconnectivity underlies the heterogeneity of schizophrenia, but these disruptions likely converge on an emergent common pathway to generate the clinical phenotype of the disorder.

CUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption

Chen IC, Kuo PH, Yang AC, Tsai SJ, Liu TH, Liu HJ, Lan TH, Chen HM, Huang HN, Chung RH, Liu YL

Scientific reports, 10(1): 18118 · 2020

We found that one or two copies of the G allele in rs671 (ALDH2) increased the risk of excessive alcohol consumption, while one or two copies of the C allele in rs3782886 (BRAP) reduced the risk of excessive alcohol consumption.

Tinnitus and risk of Alzheimer's and Parkinson's disease: a retrospective nationwide population-based cohort study

Chu HT, Liang CS, Yeh TC, Hu LY, Yang AC, Tsai SJ, Shen CC

Scientific reports, 10(1): 12134 · 2020

Our results indicate an association between tinnitus and higher risk of developing AD and PD.

An association study in the Taiwan Biobank reveals RORA as a novel locus for sleep duration in the Taiwanese Population

Hou SJ, Tsai SJ, Kuo PH, Liu YL, Yang AC, Lin E, Lan TH

Sleep medicine, 73: 70-75 · 2020

Our results indicate that the circadian clock gene RORA may contribute to sleep duration independently as well as through gene-gene and gene-environment interactions in the Taiwanese population.

Validating the Enlarged Kyd Canon: a New Approach

Yang AC

ANQ: A Quarterly Journal of Short Articles, Notes and Reviews · 2019

A computational stylometric approach is used to test and validate the enlarged canon of works attributed to the Elizabethan playwright Thomas Kyd, applying quantitative text-analysis methods to questions of literary authorship.

A powerful and efficient multivariate approach for voxel-level connectome-wide association studies

Gong W, Cheng F, Rolls ET, Lo CZ, Huang CC, Tsai SJ, Yang AC, Lin CP, Feng J

NeuroImage, 188: 628-641 · 2019

To demonstrate the utility of sKPCR for real data analysis, we have also compared sKPCR with the above methods based on the identification of voxel-wise differences between schizophrenic patients and healthy controls in four independent rsfMRI datasets.

Performing different kinds of physical exercise differentially attenuates the genetic effects on obesity measures: Evidence from 18,424 Taiwan Biobank participants

Lin WY, Chan CC, Liu YL, Yang AC, Tsai SJ, Kuo PH

PLoS genetics, 15(8): e1008277 · 2019

Our findings show that the genetic effects on obesity measures can be decreased to various extents by performing different kinds of exercise.

Increased risk of type 2 diabetes among the siblings of patients with schizophrenia

Huang MH, Chen MH, Huang KL, Hsu JW, Bai YM, Cheng CM, Su TP, Li CT, Tsai SJ, Lin WC, Yang AC, Chen TJ

CNS spectrums, 24(4): 453-459 · 2019

Logistic regression analyses with the adjustment of demographic data revealed that the unaffected siblings of patients with schizophrenia were more likely to develop T2DM (odds ratio [OR]: 1.39, 95% confidence interval [CI]: 1.10-1.75) later in life compared with the control group.

Polymorphisms of the DNA repair gene EXO1 modulate cognitive aging in old adults in a Taiwanese population

Lin E, Kuo PH, Liu YL, Yang AC, Tsai SJ

DNA repair, 78: 1-6 · 2019

Additionally, we found that interactions between the EXO1 and RAD51C genes influenced cognitive aging (P = 0.002).

Association and Interaction Effects of Interleukin-12 Related Genes and Physical Activity on Cognitive Aging in Old Adults in the Taiwanese Population

Lin E, Kuo PH, Liu YL, Yang AC, Tsai SJ

Frontiers in neurology, 10: 1065 · 2019

Evidence suggests that the neuro-inflammation mechanisms associated with interleukin-12 (IL-12) may be linked to Alzheimer's diseases and cognitive aging.

Risk of Depressive Disorders Following Myasthenia Gravis: A Nationwide Population-Based Retrospective Cohort Study

Chu HT, Tseng CC, Liang CS, Yeh TC, Hu LY, Yang AC, Tsai SJ, Shen CC

Frontiers in psychiatry, 10: 481 · 2019

The chronic autoimmune disease myasthenia gravis (MG) is characterized by fluctuating muscle weakness, which can lead to a large amount of stress in the patient.

Causal decomposition in the mutual causation system

Yang AC, Peng CK, Huang NE

Nature communications, 9(1): 3378 · 2018

Furthermore, we demonstrate the generic applicability of our method to both stochastic and deterministic systems, and show the consistency of causal-decomposition method compared to existing methods, and finally uncover the key mode of causal interactions in both modelled and actual predator-prey systems.

A Strategy to Reduce Bias of Entropy Estimates in Resting-State fMRI Signals

Yang AC, Tsai SJ, Lin CP, Peng CK

Frontiers in neuroscience, 12: 398 · 2018

Furthermore, an increased relative error of SampEn was associated with an increased coefficient of variation in voxel-wise statistics.

Frequency and amplitude modulation of resting-state fMRI signals and their functional relevance in normal aging

Yang AC, Tsai SJ, Lin CP, Peng CK, Huang NE

Neurobiology of aging, 70: 59-69 · 2018

These findings indicate that resting-state fMRI signal modulations are dynamic during the normal aging process.

Functional brain lateralization in schizophrenia based on the variability of resting-state fMRI signal

Xie W, Peng CK, Huang CC, Lin CP, Tsai SJ, Yang AC

Progress in neuro-psychopharmacology & biological psychiatry, 86: 114-121 · 2018

These results provide further evidence that abnormal variability and lateralization exist in schizophrenia patients, and abnormality in fusiform, lingual and inferior temporal could have potential help to identify the dysfunctional brain lateralization in schizophrenia.

Nonlinear dynamical analysis of sleep electroencephalography using fractal and entropy approaches

Ma Y, Shi W, Peng CK, Yang AC

Sleep medicine reviews, 37: 85-93 · 2018

The analysis of electroencephalography (EEG) recordings has attracted increasing interest in recent decades and provides the pivotal scientific tool for researchers to quantitatively study brain activity during sleep, and has extended our knowledge of the fundamental mechanisms of sleep physiology.

Effective Connectivity in Depression

Rolls ET, Cheng W, Gilson M, Qiu J, Hu Z, Ruan H, Li Y, Huang CC, Yang AC, Tsai SJ, Zhang X, Zhuang K, Lin CP, Deco G, Xie P, Feng J

Biological psychiatry. Cognitive neuroscience and neuroimaging, 3(2): 187-197 · 2018

Moreover, we show how the approach can be used to measure the differences in effective connectivity between different groups of individuals, using as an example effective connectivity in the healthy brain and in individuals with depression.

Increased functional connectivity of the posterior cingulate cortex with the lateral orbitofrontal cortex in depression

Cheng W, Rolls ET, Qiu J, Xie X, Wei D, Huang CC, Yang AC, Tsai SJ, Li Q, Meng J, Lin CP, Xie P, Feng J

Translational psychiatry, 8(1): 90 · 2018

To analyze the functioning of the posterior cingulate cortex (PCC) in depression, we performed the first fully voxel-level resting state functional-connectivity neuroimaging analysis of depression of the PCC, with 336 patients with major depressive disorder and 350 controls.

The Effects of Tai Chi on Sleep Quality in Chinese American Patients With Major Depressive Disorder: A Pilot Study

Ma Y, Yeung A, Yang AC, Peng CK, Clain A, Alpert J, Fava M, Yeung AS

Behavioral sleep medicine, 16(4): 398-411 · 2018

This pilot study evaluated the effects of Tai Chi training on sleep quality (primary outcomes), and depression and social functioning levels (secondary outcomes) among patients with depression.

Risk stratification for the early diagnosis of borderline personality disorder using psychiatric co-morbidities

Shen CC, Hu LY, Tsai SJ, Yang AC, Chen PM, Hu YH

Early intervention in psychiatry, 12(4): 605-612 · 2018

Using psychiatric co-morbidities, we identified four variables as significant risk predictors of BPD and permitted identification of subjects with low, intermediate or high risk for BPD.

Measuring Brain Complexity During Neural Motor Resonance

Hager BM, Yang AC, Gutsell JN

Frontiers in neuroscience, 12: 758 · 2018

Conclusions: The current findings suggest that the desynchronization of the mu wave during MR results in a local increase of mu entropy in sensorimotor areas, potentially reflecting a release from alpha inhibition.

Topological Pattern Recognition of Severe Alzheimer's Disease via Regularized Supervised Learning of EEG Complexity

Fan M, Yang AC, Fuh JL, Chou CA

Frontiers in neuroscience, 12: 685 · 2018

In this study, we aim to discover the altered spatio-temporal patterns of EEG complexity associated with AD pathology in different severity levels.

A Deep Learning Approach for Predicting Antidepressant Response in Major Depression Using Clinical and Genetic Biomarkers

Lin E, Kuo PH, Liu YL, Yu YW, Yang AC, Tsai SJ

Frontiers in psychiatry, 9: 290 · 2018

By using the SNP dataset that was original to a genome-wide association study, we selected 10 SNPs (including ABCA13 rs4917029, BNIP3 rs9419139, CACNA1E rs704329, EXOC4 rs6978272, GRIN2B rs7954376, LHFPL3 rs4352778, NELL1 rs2139423, NUAK1 rs2956406, PREX1 rs4810894, and SLIT3 rs139863958) which were associated with antidepressant treatment response.

Risk of Traumatic Brain Injury Among Children, Adolescents, and Young Adults With Attention-Deficit Hyperactivity Disorder in Taiwan

Liou YJ, Wei HT, Chen MH, Hsu JW, Huang KL, Bai YM, Su TP, Li CT, Yang AC, Tsai SJ, Lin WC, Chen TJ

The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 63(2): 233-238 · 2018

Our findings suggested that the public health government and clinicians should pay more attention to the TBI risk among patients with ADHD, and further indicated the importance of the optimal treatment for ADHD.

Nonlinear pattern of the emergence of white matter hyperintensity in healthy Han Chinese: an adult lifespan study

Huang CC, Yang AC, Chou KH, Liu ME, Fang SC, Chen CC, Tsai SJ, Lin CP

Neurobiology of aging, 67: 99-107 · 2018

Our findings support that the changes in WMH volume in the healthy population follow a nonlinear pattern with age, especially in PVWMH.

Callosal and subcortical white matter alterations in schizophrenia: A diffusion tensor imaging study at multiple levels

Zhao W, Guo S, He N, Yang AC, Lin CP, Tsai SJ

NeuroImage. Clinical, 20: 594-602 · 2018

We replicated these findings using an automated anatomical labeling atlas to define the network node.

Risk of sexual transmitted infection following bipolar disorder: a nationwide population-based cohort study

Lee SC, Hu CK, Hung JH, Yang AC, Tsai SJ, Huang MW, Hu LY, Shen CC

Oncotarget, 9(25): 17533-17542 · 2018

We identified patients who were diagnosed with bipolar disorder in the Taiwan National Health Insurance Research Database.

Atopic diseases/diathesis and subsequent ischemic stroke among patients with bipolar disorder: A nationwide longitudinal study

Chen LC, Chen MH, Su TP, Tsai SJ, Bai YM, Li CT, Yang AC, Chang WH, Chen TJ

PloS one, 13(8): e0200682 · 2018

Patients who experienced a stroke during the follow-up period were identified.

Combining multi-modality data for searching biomarkers in schizophrenia

Guo S, Huang CC, Zhao W, Yang AC, Lin CP, Nichols T, Tsai SJ

PloS one, 13(2): e0191202 · 2018

Our results show that, among these modalities, fMRI has the most significant featureby calculating the Jaccard similarity coefficient (0.7416) and Kappa index (0.4833).

Gene-based analysis of genes related to neurotrophic pathway suggests association of BDNF and VEGFA with antidepressant treatment-response in depressed patients

Kao CF, Liu YL, Yu YW, Yang AC, Lin E, Kuo PH, Tsai SJ

Scientific reports, 8(1): 6983 · 2018

For case-control association study, we found that all of these reported polymorphisms and genes did not reach a suggestive level.

Functional connectivity of the human amygdala in health and in depression

Cheng W, Rolls ET, Qiu J, Xie X, Lyu W, Li Y, Huang CC, Yang AC, Tsai SJ, Lyu F, Zhuang K, Lin CP, Xie P, Feng J

Social cognitive and affective neuroscience, 13(6): 557-568 · 2018

To analyse the functioning of the amygdala in depression, we performed the first voxel-level resting state functional-connectivity neuroimaging analysis of depression of voxels in the amygdala with all other voxels in the brain, with 336 patients with major depressive disorder and 350 controls.

New Targets for Schizophrenia Treatment beyond the Dopamine Hypothesis

Yang AC, Tsai SJ

International journal of molecular sciences, 18(8) · 2017

Schizophrenia has been primarily associated with dopamine dysfunction, and treatments have been developed that target the dopamine pathway in the central nervous system.

Increased Risk of Myofascial Pain Syndrome Among Patients with Insomnia

Lin WC, Shen CC, Tsai SJ, Yang AC

Pain medicine (Malden, Mass.), 18(8): 1557-1565 · 2017

Malignant neoplasm (hazard ratio = 3.08) and living in urban areas (hazard ratio = 3.05) were identified as independent risk factors for myofascial pain syndrome in patients with insomnia.

Symptomatic menopausal transition and subsequent bipolar disorder among midlife women with major depression: a nationwide longitudinal study

Chen LC, Yang AC, Su TP, Bai YM, Li CT, Chang WH, Chen TJ, Tsai SJ, Chen MH

Archives of women's mental health, 20(3): 463-468 · 2017

Cox regression analysis after adjusting for demographic data and psychiatric comorbidities further showed that symptomatic menopausal transition was associated with an increased risk of developing bipolar disorder (HR 1.14, 95% CI 1.07∼1.23) among midlife women with major depression.

The rs1277306 Variant of the REST Gene Confers Susceptibility to Cognitive Aging in an Elderly Taiwanese Population

Lin E, Tsai SJ, Kuo PH, Liu YL, Yang AC, Kao CF, Yang CH

Dementia and geriatric cognitive disorders, 43(3-4): 119-127 · 2017

However, the 3-marker haplotype derived from the rs1713985, rs3796529, and rs7680734 SNPs in the REST gene demonstrated no association with cognitive aging.

Quality and readability of online information resources on insomnia

Ma Y, Yang AC, Duan Y, Dong M, Yeung AS

Frontiers of medicine, 11(3): 423-431 · 2017

This study aimed to evaluate the quality and readability of insomnia-related online information.

Depression and the risk of vascular dementia: a population-based retrospective cohort study

Lin WC, Hu LY, Tsai SJ, Yang AC, Shen CC

International journal of geriatric psychiatry, 32(5): 556-563 · 2017

Our findings suggest that depression is an independent risk factor for subsequent VaD.

Bidirectional association between Bell's palsy and anxiety disorders: A nationwide population-based retrospective cohort study

Tseng CC, Hu LY, Liu ME, Yang AC, Shen CC, Tsai SJ

Journal of affective disorders, 215: 269-273 · 2017

In this study, we used the Taiwan National Health Insurance Research Database (NHIRD) to test the bidirectional association between Bell's palsy and anxiety disorders.

Neural complexity as a potential translational biomarker for psychosis

Hager B, Yang AC, Brady R, Meda S, Clementz B, Pearlson GD, Sweeney JA, Tamminga C, Keshavan M

Journal of affective disorders, 216: 89-99 · 2017

Furthermore, we found significant differences as well as overlaps of pathologic brain signal complexity between psychotic probands by DSM diagnoses, thus suggesting a biological approach to categorizing psychosis based on functional neuroimaging data.

Detection of susceptibility loci on APOA5 and COLEC12 associated with metabolic syndrome using a genome-wide association study in a Taiwanese population

Lin E, Kuo PH, Liu YL, Yang AC, Tsai SJ

Oncotarget, 8(55): 93349-93359 · 2017

Additionally, we found that an interaction between the APOA5 rs662799 and COLEC12 rs16944558 SNPs influenced MetS, high triglyceride, and low HDL.

Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population

Lin E, Kuo PH, Liu YL, Yang AC, Kao CF, Tsai SJ

Oncotarget, 8(15): 24088-24098 · 2017

In this study, we assessed whether 11 circadian clockgenes are associated with cognitive aging independently and/or through complex interactions in an old Taiwanese population.

Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population

Lin E, Tsai SJ, Kuo PH, Liu YL, Yang AC, Kao CF

Oncotarget, 8(15): 24077-24087 · 2017

Additionally, we found the interactions among CASS4-rs911159, EPHA-rs10952552, FERMT2-rs4901317, MEF2C-rs9293506, or SLC24A4-rs67063100 on cognitive aging (P = 0.004~0.035).

Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis

Lin E, Kuo PH, Liu YL, Yang AC, Kao CF, Tsai SJ

PloS one, 12(3): e0173861 · 2017

Additionally, we found interactions among the ARNTL rs10832020, GSK3B rs2199503, PER3 rs10746473, RORA rs8034880, and RORB rs972902 SNPs influenced MetS (P < 0.001 ~ P = 0.002).

The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population

Lin E, Tsai SJ, Kuo PH, Liu YL, Yang AC, Kao CF, Yang CH

PloS one, 12(2): e0172440 · 2017

Additionally, we found that interactions between the ADAMTS9 rs9985304 and ADAMTS9 rs76346246 SNPs influenced cognitive aging (P < 0.001).

Measuring information-based energy and temperature of literary texts

Chang MC, Yang AC, Stanley HE, Peng CK

Physica A: Statistical Mechanics and its Applications, 468: 783-789 · 2017

Borrowing concepts from statistical physics, the authors define an information-based 'energy' and 'temperature' of literary texts, providing a thermodynamic-style framework to characterize the complexity and style of written language.

Transforming growth factor-β signaling pathway-associated genes SMAD2 and TGFBR2 are implicated in metabolic syndrome in a Taiwanese population

Lin E, Kuo PH, Liu YL, Yang AC, Tsai SJ

Scientific reports, 7(1): 13589 · 2017

Our findings indicated that the TGF-β signaling pathway-associated genes of SMAD2 and TGFBR2 may contribute to the risk of MetS independently and through gene-gene interactions.

The Association of Aging with White Matter Integrity and Functional Connectivity Hubs

Yang AC, Tsai SJ, Liu ME, Huang CC, Lin CP

Frontiers in aging neuroscience, 8: 143 · 2016

These results support the compensatory hypothesis of neurocognitive aging theory and reveal the DTI-fMRI relationship associated with normal aging.

Cyclic Cushing's syndrome mimicking bipolar disorder

Tsai WT, Tsai SJ, Yang AC

Psychiatry and clinical neurosciences, 70(1): 71 · 2016

Case report of cyclic Cushing's syndrome presenting with mood instability that mimicked bipolar disorder, highlighting endocrine causes of psychiatric presentations.

Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression

Cheng W, Rolls ET, Qiu J, Liu W, Tang Y, Huang CC, Wang X, Zhang J, Lin W, Zheng L, Pu J, Tsai SJ, Yang AC, Lin CP, Wang F, Xie P, Feng J

Brain : a journal of neurology, 139(Pt 12): 3296-3309 · 2016

The first brain-wide voxel-level resting state functional connectivity neuroimaging analysis of depression is reported, with 421 patients with major depressive disorder and 488 control subjects.

Risk of uterine, ovarian and breast cancer following pelvic inflammatory disease: a nationwide population-based retrospective cohort study

Shen CC, Hu LY, Yang AC, Chiang YY, Hung JH, Tsai SJ

BMC cancer, 16(1): 839 · 2016

This large nationwide population-based cohort study suggests that there is no increased risk for ovarian, breast or uterine cancer among women who have PID compared to a matching population.

Risk for developing dementia among patients with posttraumatic stress disorder: A nationwide longitudinal study

Wang TY, Wei HT, Liou YJ, Su TP, Bai YM, Tsai SJ, Yang AC, Chen TJ, Tsai CF, Chen MH

Journal of affective disorders, 205: 306-310 · 2016

The importance of mental care for trauma victims would increase in the coming century, and our findings broadened another era for the end result of a widely prevalent psychiatric disorder.

Risk of depressive disorders following sudden sensorineural hearing loss: A nationwide population-based retrospective cohort study

Tseng CC, Hu LY, Liu ME, Yang AC, Shen CC, Tsai SJ

Journal of affective disorders, 197: 94-9 · 2016

From the National Health Insurance Research Database (NHIRD) in Taiwan, we identified new SSNHL patients diagnosed by an otolaryngologist between January 01, 2000, and December 31, 2008.

Risk of developing major depression and anxiety disorders among women with endometriosis: A longitudinal follow-up study

Chen LC, Hsu JW, Huang KL, Bai YM, Su TP, Li CT, Yang AC, Chang WH, Chen TJ, Tsai SJ, Chen MH

Journal of affective disorders, 190: 282-285 · 2016

Endometriosis was associated with an elevated likelihood of developing depression and anxiety disorders.

Resting-state EEG power and coherence vary between migraine phases

Cao Z, Lin CT, Chuang CH, Lai KL, Yang AC, Fuh JL, Wang SJ

The journal of headache and pain, 17(1): 102 · 2016

Migraine is characterized by a series of phases (inter-ictal, pre-ictal, ictal, and post-ictal).

Sensitivity enhancement of task-evoked fMRI using ensemble empirical mode decomposition

Lin SH, Lin GH, Tsai PJ, Hsu AL, Lo MT, Yang AC, Lin CP, Wu CW

Journal of neuroscience methods, 258: 56-66 · 2016

We found that EEMD method was efficient to enhance the functional sensitivity of evoked fMRI.

Risk of psychiatric disorders following pelvic inflammatory disease: a nationwide population-based retrospective cohort study

Shen CC, Yang AC, Hung JH, Hu LY, Chiang YY, Tsai SJ

Journal of psychosomatic obstetrics and gynaecology, 37(1): 6-11 · 2016

Our findings highlight that clinicians should pay particular attention to psychiatric comorbidities in PID patients.

Risk of Psychiatric Disorders following Ankylosing Spondylitis: A Nationwide Population-based Retrospective Cohort Study

Shen CC, Hu LY, Yang AC, Kuo BI, Chiang YY, Tsai SJ

The Journal of rheumatology, 43(3): 625-31 · 2016

We identified subjects who were newly diagnosed with AS between January 1, 2000, and December 31, 2008, in the Taiwan National Health Insurance (NHI) Research Database.

Heart Rate Variability Is Associated with Exercise Capacity in Patients with Cardiac Syndrome X

Lu DY, Yang AC, Cheng HM, Lu TM, Yu WC, Chen CH, Sung SH

PloS one, 11(1): e0144935 · 2016

In subgroup analysis, HRV indices demonstrated similar predictive values related to exercise capacity across various subpopulations, especially in the young.

On Holo-Hilbert spectral analysis: a full informational spectral representation for nonlinear and non-stationary data

Huang NE, Hu K, Yang AC, Chang HC, Jia D, Liang WK, Yeh JR, Kao CL, Juan CH, Peng CK, Meijer JH, Wang YH, Long SR, Wu Z

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 374(2065): 20150206 · 2016

The Holo-Hilbert spectral analysis (HHSA) method is introduced to cure the deficiencies of traditional spectral analysis and to give a full informational representation of nonlinear and non-stationary data.

Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population

Lin E, Kuo PH, Liu YL, Yang AC, Kao CF, Tsai SJ

Scientific reports, 6: 36830 · 2016

Additionally, we found the interactions of APOA5 rs662799, BUD13 rs11216129, BUD13 rs623908, CETP rs820299, LIPA rs1412444, alcohol consumption, smoking status, or physical activity on MetS and its individual components.

Effect of Alzheimer's Disease Risk Variant rs3824968 at SORL1 on Regional Gray Matter Volume and Age-Related Interaction in Adult Lifespan

Huang CC, Liu ME, Kao HW, Chou KH, Yang AC, Wang YH, Chen TR, Tsai SJ, Lin CP

Scientific reports, 6: 23362 · 2016

These findings provide evidence that SORL1 rs3824968 modulates regional GM volume and is associated with brain trajectory during the adult lifespan.

Decreased resting-state brain activity complexity in schizophrenia characterized by both increased regularity and randomness

Yang AC, Hong CJ, Liou YJ, Huang KL, Huang CC, Liu ME, Lo MT, Huang NE, Peng CK, Lin CP, Tsai SJ

Human brain mapping, 36(6): 2174-86 · 2015

These results collectively suggested that resting-state dynamics in schizophrenia exhibit two routes of pathologic change toward regular or random patterns, which contribute to the differences in syndrome domains of psychosis in patients with schizophrenia.

Patients with migraine are right about their perception of temperature as a trigger: time series analysis of headache diary data

Yang AC, Fuh JL, Huang NE, Shia BC, Wang SJ

The journal of headache and pain, 16: 533 · 2015

This diary-based study provides evidence to link the perception of temperature sensitivity and headache incidence in migraine patients.

Functional Connectivity Density Mapping of Depressive Symptoms and Loneliness in Non-Demented Elderly Male

Lan CC, Tsai SJ, Huang CC, Wang YH, Chen TR, Yeh HL, Liu ME, Lin CP, Yang AC

Frontiers in aging neuroscience, 7: 251 · 2015

Loneliness is associated with FCD changes in bilateral lingual gyri that are known to be important in social cognition.

Publication analysis on insomnia: how much has been done in the past two decades?

Ma Y, Dong M, Mita C, Sun S, Peng CK, Yang AC

Sleep medicine, 16(7): 820-6 · 2015

Furthermore, we found that while studies on drug therapy and adverse effects decreased in the most recent five years, the greatest expansion of insomnia publications were in the areas of cognitive behavioral therapy for insomnia (CBT-I) and alternative therapies.

Risk of developing Parkinson's disease among patients with asthma: a nationwide longitudinal study

Cheng CM, Wu YH, Tsai SJ, Bai YM, Hsu JW, Huang KL, Su TP, Li CT, Tsai CF, Yang AC, Lin WC, Pan TL, Chang WH, Chen TJ, Chen MH

Allergy, 70(12): 1605-12 · 2015

Those who developed Parkinson's disease during the follow-up period were identified.

Risk of psychiatric disorders following gastroesophageal reflux disease: a nationwide population-based cohort study

You ZH, Perng CL, Hu LY, Lu T, Chen PM, Yang AC, Tsai SJ, Huang YS, Chen HJ

European journal of internal medicine, 26(7): 534-9 · 2015

Recent studies have shown that the peripheral inflammation may cause the up-regulation of central nervous system inflammation and therefore possibly plays a vital role in the pathophysiology of subsequent psychiatric disorders.

Risk of developing major depressive disorder and anxiety disorders among adolescents and adults with atopic dermatitis: a nationwide longitudinal study

Cheng CM, Hsu JW, Huang KL, Bai YM, Su TP, Li CT, Yang AC, Chang WH, Chen TJ, Tsai SJ, Chen MH

Journal of affective disorders, 178: 60-5 · 2015

Subjects who developed major depression, any depressive disorder, and anxiety disorders during the follow-up were identified.

Comorbidity of ADHD and suicide attempts among adolescents and young adults with bipolar disorder: A nationwide longitudinal study

Lan WH, Bai YM, Hsu JW, Huang KL, Su TP, Li CT, Yang AC, Lin WC, Chang WH, Chen TJ, Tsai SJ, Chen MH

Journal of affective disorders, 176: 171-5 · 2015

Using Taiwan׳s National Health Insurance Research Database, we identified 500 adolescents and young adults from 2002 to 2008 aged between 15 and 24 years with bipolar disorder and ADHD.

Bidirectional Association Between Depression and Fibromyalgia Syndrome: A Nationwide Longitudinal Study

Chang MH, Hsu JW, Huang KL, Su TP, Bai YM, Li CT, Yang AC, Chang WH, Chen TJ, Tsai SJ, Chen MH

The journal of pain, 16(9): 895-902 · 2015

Our results supported a bidirectional temporal association between depression and FMS.

Risk of Psychiatric Disorders Following Primary Sjögren Syndrome: A Nationwide Population-based Retrospective Cohort Study

Shen CC, Yang AC, Kuo BI, Tsai SJ

The Journal of rheumatology, 42(7): 1203-8 · 2015

Our findings highlight the need for psychiatric evaluation and intervention for patients with pSS.

Association of depression and loneliness with specific cognitive performance in non-demented elderly males

Tzang RF, Yang AC, Yeh HL, Liu ME, Tsai SJ

Medical science monitor : international medical journal of experimental and clinical research, 21: 100-4 · 2015

Our findings suggest that loneliness and depression may have negative impacts on global and specific domains of cognitive function in non-demented elderly males.

A nationwide population-based retrospective cohort study of the risk of uterine, ovarian and breast cancer in women with polycystic ovary syndrome

Shen CC, Yang AC, Hung JH, Hu LY, Tsai SJ

The oncologist, 20(1): 45-9 · 2015

We identified subjects who were diagnosed with PCOS between January 1, 2000, and December 31, 2004, in the Taiwan National Health Insurance (NHI) Research Database.

Statins Reduces the Risk of Dementia in Patients with Late-Onset Depression: A Retrospective Cohort Study

Yang YH, Teng HW, Lai YT, Li SY, Lin CC, Yang AC, Chan HL, Hsieh YH, Lin CF, Hsu FY, Liu CK, Liu WS

PloS one, 10(9): e0137914 · 2015

Patients with late-onset depression (LOD) have been reported to run a higher risk of subsequent dementia.

Risk of Psychiatric Disorders following Irritable Bowel Syndrome: A Nationwide Population-Based Cohort Study

Lee YT, Hu LY, Shen CC, Huang MW, Tsai SJ, Yang AC, Hu CK, Perng CL, Huang YS, Hung JH

PloS one, 10(7): e0133283 · 2015

Irritable bowel syndrome (IBS) is the most common functional gastrointestinal (GI) disorder observed in patients who visit general practitioners for GI-related complaints.

The APOE ɛ4 allele affects complexity and functional connectivity of resting brain activity in healthy adults

Yang AC, Huang CC, Liu ME, Liou YJ, Hong CJ, Lo MT, Huang NE, Peng CK, Lin CP, Tsai SJ

Human brain mapping, 35(7): 3238-48 · 2014

These results support the compensatory recruitment hypothesis in older APOE ɛ4 carriers, and confer the impact of the APOE genotype on the temporal dynamics of brain activity in older adults.

Pisa syndrome after discontinuation of clotiapine in a patient with intractable insomnia

Wang EH, Yang AC

Journal of clinical psychopharmacology, 34(2): 276-7 · 2014

Case report of Pisa syndrome (tonic lateral trunk flexion) emerging after clotiapine discontinuation in a patient with intractable insomnia.

Local awakening: regional reorganizations of brain oscillations after sleep

Tsai PJ, Chen SC, Hsu CY, Wu CW, Wu YC, Hung CS, Yang AC, Liu PY, Biswal B, Lin CP

NeuroImage, 102 Pt 2: 894-903 · 2014

In conclusion, the regional specificity and the stage effect were verified in support of the local awakening concept, indicating that sleep regulation leads to the reorganization of brain networks upon awakening.

Revealing the brain's adaptability and the transcranial direct current stimulation facilitating effect in inhibitory control by multiscale entropy

Liang WK, Lo MT, Yang AC, Peng CK, Cheng SK, Tseng P, Juan CH

NeuroImage, 90: 218-34 · 2014

We found that tDCS can further increase the EEG complexity of the frontal lobe.

Effect of BDNF Val66Met polymorphism on regional white matter hyperintensities and cognitive function in elderly males without dementia

Huang CC, Liu ME, Chou KH, Yang AC, Hung CC, Hong CJ, Tsai SJ, Lin CP

Psychoneuroendocrinology, 39: 94-103 · 2014

Our findings supported the hypothesis that the BDNF Val66Met polymorphism may affect susceptibility to regional WMH volume and such genotype-by-WMH interaction effect is correlated with cognitive decline in non-demented elderly males, in which the Met allele plays a protective role.

The association of physical activity to neural adaptability during visuo-spatial processing in healthy elderly adults: A multiscale entropy analysis

Wang CH, Tsai CL, Tseng P, Yang AC, Lo MT, Peng CK, Wang HY, Muggleton NG, Juan CH, Liang WK

Brain and cognition, 92C: 73-83 · 2014

The results suggest that physical activity may be beneficial for adaptability of brain systems in tasks involving visuo-spatial information.

Interleukin-1 beta C-511T polymorphism modulates functional connectivity of anterior midcingulate cortex in non-demented elderly Han males

Tu PC, Su TP, Huang CC, Yang AC, Yeh HL, Hong CJ, Liou YJ, Liu ME, Lin CP, Tsai SJ

Brain structure & function, 219(1): 61-9 · 2014

Recent resting fMRI studies have suggested that the functional connectivity of the brain's large-scale networks is associated with the cognitive decline of aging and is modulated by genetic factors.

Temperature variation and the incidence of cluster headache periods: A nationwide population study

Lee YJ, Chen YT, Ou SM, Li SY, Yang AC, Tang CH, Wang SJ

Cephalalgia : an international journal of headache, 34(9): 656-663 · 2014

Either an increase or a decrease in temperature (0.05℃/day) following a warm period (mean temperature ≥26℃) was associated with the onset of cluster periods.

The association of RAB18 gene polymorphism (rs3765133) with cerebellar volume in healthy adults

Cheng CY, Yang AC, Huang CC, Liu ME, Liou YJ, Wu JC, Tsai SJ, Lin CP, Hong CJ

Cerebellum (London, England), 13(5): 616-22 · 2014

Our findings suggest that RAB18 rs3765133 polymorphism affects the deve-lopment of specific brain regions, particularly the cerebellum, in healthy people.

Effect of the BDNF Val66Met polymorphism on regional gray matter volumes and cognitive function in the Chinese population

Liu ME, Huang CC, Chen MH, Yang AC, Tu PC, Yeh HL, Hong CJ, Chen JF, Hwang JP, Lin CP, Tsai SJ

Neuromolecular medicine, 16(1): 127-36 · 2014

Our findings suggest that the presence of two Met alleles has a protective effect on regional GM volumes in the Chinese population.

APOE ɛ4 polymorphism and cognitive deficit among the very old Chinese veteran men without dementia

Chu CS, Lu T, Tsai SJ, Hong CJ, Yeh HL, Yang AC, Liu ME

Neuroscience letters, 576: 17-21 · 2014

This study suggests that the APOE ɛ4 alleles contributed detrimental effects on cognitive function in the very old veterans who do not have dementia.

Risk of developing depressive disorders following rheumatoid arthritis: a nationwide population-based study

Wang SL, Chang CH, Hu LY, Tsai SJ, Yang AC, You ZH

PloS one, 9(9): e107791 · 2014

To evaluate the risk of depressive disorders among rheumatoid arthritis (RA) by using the Taiwan National Health Insurance Research Database (NHIRD).

Risk of psychiatric disorders following polycystic ovary syndrome: a nationwide population-based cohort study

Hung JH, Hu LY, Tsai SJ, Yang AC, Huang MW, Chen PM, Wang SL, Lu T, Shen CC

PloS one, 9(5): e97041 · 2014

We identified patients who were diagnosed with PCOS by an obstetrician-gynecologist in the Taiwan National Health Insurance Research Database.

Catechol-O-methyltransferase Val158Met polymorphism on the relationship between white matter hyperintensity and cognition in healthy people

Liu ME, Huang CC, Yang AC, Tu PC, Yeh HL, Hong CJ, Liou YJ, Chen JF, Chou KH, Lin CP, Tsai SJ

PloS one, 9(2): e88749 · 2014

The effect size (cohen's f) revealed a small effect.

Sleep apnea and the subsequent risk of breast cancer in women: a nationwide population-based cohort study

Chang WP, Liu ME, Chang WC, Yang AC, Ku YC, Pai JT, Lin YW, Tsai SJ

Sleep medicine, 15(9): 1016-20 · 2014

Despite not meeting statistical significance, we found increases in the risk of breast cancer in women aged 30-59 years (HR, 2.06; 95% CI, 0.90-4.70) and ≥60 years (HR, 3.05; 95% CI, 0.90-10.32) compared with those aged 0-29 years.

Cognitive and neuropsychiatric correlates of EEG dynamic complexity in patients with Alzheimer's disease

Yang AC, Wang SJ, Lai KL, Tsai CF, Yang CH, Hwang JP, Lo MT, Huang NE, Peng CK, Fuh JL

Progress in neuro-psychopharmacology & biological psychiatry, 47: 52-61 · 2013

MSE analysis revealed abnormal EEG complexity across short- and long-time scales that were correlated to cognitive and neuropsychiatric assessments.

Complexity of mental illness: a new research dimension

Yang AC, Tsai SJ

Progress in neuro-psychopharmacology & biological psychiatry, 45: 251-2 · 2013

Editorial proposing 'complexity' — quantified across behaviour and brain dynamics — as a new research dimension for understanding mental illness.

Is mental illness complex? From behavior to brain

Yang AC, Tsai SJ

Progress in neuro-psychopharmacology & biological psychiatry, 45: 253-7 · 2013

A defining but elusive feature of the human brain is its astonishing complexity.

Effects of age, sex, index admission, and predominant polarity on the seasonality of acute admissions for bipolar disorder: a population-based study

Yang AC, Yang CH, Hong CJ, Liou YJ, Shia BC, Peng CK, Huang NE, Tsai SJ

Chronobiology international, 30(4): 478-85 · 2013

These findings highlight the need for research on identification and management of seasonal features in bipolar patients.

Complexity of spontaneous BOLD activity in default mode network is correlated with cognitive function in normal male elderly: a multiscale entropy analysis

Yang AC, Huang CC, Yeh HL, Liu ME, Hong CJ, Tu PC, Chen JF, Huang NE, Peng CK, Lin CP, Tsai SJ

Neurobiology of aging, 34(2): 428-38 · 2013

Our findings confirmed the hypothesis that complexity of BOLD activity was correlated with aging and cognitive performance based on MSE analysis, and may provide insights on how dynamics of spontaneous brain activity relates to aging and cognitive function in specific brain regions.

Suicide and media reporting: a longitudinal and spatial analysis

Yang AC, Tsai SJ, Yang CH, Shia BC, Fuh JL, Wang SJ, Peng CK, Huang NE

Social psychiatry and psychiatric epidemiology, 48(3): 427-35 · 2013

This study investigated the association of suicide deaths with suicide news in longitudinal and spatial dimensions.

Risk of Parkinson disease after depression: a nationwide population-based study

Shen CC, Tsai SJ, Perng CL, Kuo BI, Yang AC

Neurology, 81(17): 1538-44 · 2013

To evaluate the risk of Parkinson disease (PD) among patients with depression by using the Taiwan National Health Insurance Research Database (NHIRD).

On-call duty effects on sleep-state physiological stability in male medical interns

Lin YH, Ho YC, Lin SH, Yeh YH, Liu CY, Kuo TB, Yang CC, Yang AC

PloS one, 8(6): e65072 · 2013

The ECG-based CPC analysis provides a straightforward means to quantify sleep quality and stability in medical staff performing shift work under stressful conditions.

Reversible skin rash in a bipolar disorder patient on first use of lithium

Wang EH, Yang AC

Psychiatry and clinical neurosciences, 67(5): 365 · 2013

Case report of a reversible skin rash in a bipolar patient on a first-generation antipsychotic, informing drug-safety monitoring.

Effect of Bcl-2 rs956572 SNP on regional gray matter volumes and cognitive function in elderly males without dementia

Liu ME, Huang CC, Hwang JP, Yang AC, Tu PC, Yeh HL, Hong CJ, Liou YJ, Chen JF, Lin CP, Tsai SJ

Age (Dordrecht, Netherlands), 35(2): 343-52 · 2013

The findings suggest that Bcl-2 rs956572 SNP may modulate cognitive function and regional GM volume in non-demented elderly men, and that this polymorphism may affect language performance through its effect on the right MTG.

Physiologic and laboratory correlates of depression, anxiety, and poor sleep in liver cirrhosis

Ko FY, Yang AC, Tsai SJ, Zhou Y, Xu LM

BMC gastroenterology, 13: 18 · 2013

Increased serum AST and abnormal autonomic nervous activities by HRV analysis were associated with psychological distress in cirrhosis.

Incidence and outcome of newly-diagnosed tuberculosis in schizophrenics: a 12-year, nationwide, retrospective longitudinal study

Kuo SC, Chen YT, Li SY, Lee YT, Yang AC, Chen TL, Liu CJ, Chen TJ, Su IJ, Fung CP

BMC infectious diseases, 13: 351 · 2013

Cox regression revealed age and male gender as risk factors for newly-diagnosed TB.

Association of CD8 T cells with depression and anxiety in patients with liver cirrhosis

Ko FY, Tsai SJ, Yang AC, Zhou Y, Xu LM

International journal of psychiatry in medicine, 45(1): 15-29 · 2013

Our findings are the first to show that depression and anxiety may be associated with increased levels of CD8 in T-lymphocyte subsets in cirrhosis patients, suggesting that an imbalance of T-lymphocyte subsets may be a factor facilitating depression and anxiety in cirrhotic patients.

Autonomic dysfunction in reversible cerebral vasoconstriction syndromes

Chen SP, Yang AC, Fuh JL, Wang SJ

The journal of headache and pain, 14(1): 94 · 2013

This study aimed to assess the autonomic function by analyzing heart rate variability (HRV) in patients with RCVS.

Interleukin-1 alpha (rs1800587) genetic polymorphism is associated with specific cognitive functions but not depression or loneliness in elderly males without dementia

Wang EH, Hong CJ, Yeh HL, Liou YJ, Yang AC, Liu ME, Tsai SJ

Neuroscience letters, 556: 69-72 · 2013

Our data supports that the T allele of IL-1A rs1800587 genetic polymorphism is associated with better cognitive function in the elderly.

Sleep apnea and the risk of dementia: a population-based 5-year follow-up study in Taiwan

Chang WP, Liu ME, Chang WC, Yang AC, Ku YC, Pai JT, Huang HL, Tsai SJ

PloS one, 8(10): e78655 · 2013

The SA patients in this study had a 1.70-times greater risk of developing dementia within 5 years of diagnosis compared to non-SA age- and sex-matched patients, after adjusting for other risk factors (95% confidence interval (CI) = 1.26-2.31; P < .01).

The effect of cold temperature on increased exacerbation of chronic obstructive pulmonary disease: a nationwide study

Tseng CM, Chen YT, Ou SM, Hsiao YH, Li SY, Wang SJ, Yang AC, Chen TJ, Perng DW

PloS one, 8(3): e57066 · 2013

This study demonstrated the effect of cold temperatures on the COPD exacerbation rate.

Effect of Bcl-2 rs956572 polymorphism on age-related gray matter volume changes

Liu ME, Huang CC, Yang AC, Tu PC, Yeh HL, Hong CJ, Chen JF, Liou YJ, Lin CP, Tsai SJ

PloS one, 8(2): e56663 · 2013

We found that the volume of these five regions decreased with increasing age (all P<.001).

Association of altered cardiac autonomic function with psychopathology and metabolic profiles in schizophrenia

Chung MS, Yang AC, Lin YC, Lin CN, Chang FR, Shen SH, Ouyang WC, Loh el-W, Chiu HJ

Psychiatry research, 210(3): 710-5 · 2013

These findings may warrant future research in using HRV as objective markers to monitor cardiovascular health and the severity of psychosis in patients with schizophrenia.

Daytime sleepiness: a risk factor for poor social engagement among the elderly

Lee YT, Tsai CF, Ouyang WC, Yang AC, Yang CH, Hwang JP

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 13(4): 213-20 · 2013

The aim of this study was to investigate the relationship between social engagement and daytime sleepiness among aged residents of a veterans' housing facility in Taiwan.

Association of BACE1 Gene Polymorphism with Cerebellar Volume but Not Cognitive Function in Normal Individuals

Tsai A, Huang CC, Yang AC, Liu ME, Tu PC, Hong CJ, Liou YJ, Chen JF, Lin CP, Tsai SJ

Dementia and geriatric cognitive disorders extra, 2(1): 632-7 · 2012

The findings suggest that the BACE1 rs638405 polymorphism may affect cerebellar morphology, but not cognitive function in healthy humans.

Association of CHRNA4 polymorphism with depression and loneliness in elderly males

Tsai SJ, Yeh HL, Hong CJ, Liou YJ, Yang AC, Liu ME, Hwang JP

Genes, brain, and behavior, 11(2): 230-4 · 2012

Study findings identified a significant link between the CHRNA4:rs1044396 polymorphism and depression and loneliness in the aged.

Association of MTHFR C677T polymorphism with loneliness but not depression in cognitively normal elderly males

Lan WH, Yang AC, Hwang JP, Hong CJ, Liou YJ, Yeh HL, Liu ME, Tsai SJ

Neuroscience letters, 521(1): 88-91 · 2012

Our findings suggest that MTHFR C677T polymorphism may be linked more to loneliness than depression in the cognitively normal elderly males, and may be implicated in the pathophysiology of late-life depression in relation to MTHFR genes.

Association of Internet search trends with suicide death in Taipei City, Taiwan, 2004-2009

Yang AC, Tsai SJ, Huang NE, Peng CK

Journal of affective disorders, 132(1-2): 179-84 · 2011

Results show that a set of suicide-related search terms, the trends of which either temporally coincided or preceded trends of suicide data, were associated with suicide death.

Reduced physiologic complexity is associated with poor sleep in patients with major depression and primary insomnia

Yang AC, Tsai SJ, Yang CH, Kuo CH, Chen TJ, Hong CJ

Journal of affective disorders, 131(1-3): 179-85 · 2011

These findings could highlight the importance of treating insomnia as an independent disease rather than a symptom.

Decomposing the association of completed suicide with air pollution, weather, and unemployment data at different time scales

Yang AC, Tsai SJ, Huang NE

Journal of affective disorders, 129(1-3): 275-81 · 2011

This study comprehensively assesses the temporal relationship between suicide and air pollution, weather, and unemployment variables in Taipei City from January 1 1991 to December 31 2008.

Clustering heart rate dynamics is associated with β-adrenergic receptor polymorphisms: analysis by information-based similarity index

Yang AC, Tsai SJ, Hong CJ, Wang C, Chen TJ, Liou YJ, Peng CK

PloS one, 6(5): e19232 · 2011

Our results provide evidence that β(2)-AR polymorphisms are significantly associated with the acceleration/deceleration pattern of heart rate oscillation, reflecting the underlying mode of autonomic nervous system control.

Temporal associations between weather and headache: analysis by empirical mode decomposition

Yang AC, Fuh JL, Huang NE, Shia BC, Peng CK, Wang SJ

PloS one, 6(1): e14612 · 2011

We found no associations between the raw time series of weather variables and headache incidence.

Sleep state instabilities in major depressive disorder: Detection and quantification with electrocardiogram-based cardiopulmonary coupling analysis

Yang AC, Yang CH, Hong CJ, Tsai SJ, Kuo CH, Peng CK, Mietus JE, Goldberger AL, Thomas RJ

Psychophysiology, 48(2): 285-91 · 2011

Sleep disruption is an important aspect of major depressive disorder but lacks an objective and inexpensive means of assessment.

Brain-derived neurotrophic factor gene Val66Met polymorphism modulates reversible cerebral vasoconstriction syndromes

Chen SP, Fuh JL, Wang SJ, Tsai SJ, Hong CJ, Yang AC

PloS one, 6(3): e18024 · 2011

Our findings link BDNF Val66Met polymorphism with the severity of RCVS for the first time and implicate possible pathogenic mechanisms for vasoconstriction in RCVS.

Heterozygote advantage of the MTHFR C677T polymorphism on specific cognitive performance in elderly Chinese males without dementia

Tsai SJ, Hong CJ, Yeh HL, Liou YJ, Yang AC, Liu ME, Hwang JP

Dementia and geriatric cognitive disorders, 32(3): 159-63 · 2011

These results suggest that a heterozygote advantage exists for the MTHFR C677T polymorphism in specific cognitive functions in elderly Chinese males without dementia.

Myasthenic crisis may mimic antipsychotic-induced extrapyramidal syndromes

Chiu YH, Yang AC, Chern CH, How CK

The Journal of neuropsychiatry and clinical neurosciences, 23(2): E36-7 · 2011

Case report showing myasthenic crisis can mimic antipsychotic-induced extrapyramidal syndromes — an important differential-diagnosis caution.

Polymorphisms in LMNA and near a SERPINA13 gene are not associated with cognitive performance in Chinese elderly males without dementia

Yeh HL, Hou SJ, Yen FC, Hong CJ, Liou YJ, Yang AC, Liu ME, Tsai SJ

Neuroscience letters, 504(1): 32-4 · 2011

This study replicated these findings in Chinese elderly males without dementia.

BDNF Val66Met polymorphism alters sympathovagal balance in healthy subjects

Yang AC, Chen TJ, Tsai SJ, Hong CJ, Kuo CH, Yang CH, Kao KP

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 153B(5): 1024-30 · 2010

These results suggest that an altered sympathovagal balance with relatively decreased parasympathetic activity is associated with the Met/Met genotype, suggesting a potential role for the studied BDNF polymorphism in modulating cardiac autonomic functions.

Association between renal function and cognitive performance in elderly community-dwelling men without dementia

Yang AC, Tsai SJ, Yeh HL, Chen JY, Liou YJ, Hwang JP, Hong CJ

Journal of the American Geriatrics Society, 58(10): 2046-8 · 2010

Population study linking reduced renal function to poorer cognitive performance in community-dwelling elderly men without dementia.

Do seasons have an influence on the incidence of depression? The use of an internet search engine query data as a proxy of human affect

Yang AC, Huang NE, Peng CK, Tsai SJ

PloS one, 5(10): e13728 · 2010

Our findings indicate that Internet searches for depression from people in higher latitudes are more vulnerable to seasonal change, whereas this phenomenon is obscured in tropical areas.

Profiling objective sleep quality in a healthy Taiwanese sample using a novel electrocardiogram-based cardiopulmonary coupling analysis

Yang AC, et al.

Taiwanese Journal of Psychiatry, 24(3): 201-211 · 2010

Using a validated electrocardiogram-based cardiopulmonary coupling (CPC) analysis in 155 healthy Taiwanese subjects, this study profiles how age and gender affect sleep-related cardiovascular and respiratory dynamics, establishing normative objective sleep-quality references.

Heart rate variability in psychiatric disorders

Yang AC, et al.

Taiwanese Journal of Psychiatry, 24(2): 99-109 · 2010

A review introducing the principles and techniques of heart rate variability (HRV) analysis and illustrating how autonomic nervous system dysregulation, measured by HRV, is associated with psychopathology and cardiovascular comorbidity in psychiatric disorders.

Reduced physiological complexity in robust elderly adults with the APOE epsilon4 allele

Cheng D, Tsai SJ, Hong CJ, Yang AC

PloS one, 4(11): e7733 · 2009

A total of 102 robust, non-demented, elderly subjects with normal functions of daily activities participated in this study (97 males and 5 females, aged 79.2+/-4.4 years, range 72-92 years).

Association between heart rate variability and cognitive function in elderly community-dwelling men without dementia: a preliminary report

Yang AC, Tsai SJ, Hong CJ, Yang CH, Hsieh CH, Liu ME

Journal of the American Geriatrics Society, 56(5): 958-60 · 2008

Early study associating greater heart-rate-variability complexity with better cognitive function in non-demented elderly men, linking autonomic and brain health.

Statistical physics approach to categorize biologic signals: from heart rate dynamics to DNA sequences

Peng CK, Yang AC, Goldberger AL

Chaos (Woodbury, N.Y.), 17(1): 015115 · 2007

We recently proposed a novel approach to categorize information carried by symbolic sequences based on their usage of repetitive patterns.

Genomic classification using an information-based similarity index: application to the SARS coronavirus

Yang AC, Goldberger AL, Peng CK

Journal of computational biology : a journal of computational molecular cell biology, 12(8): 1103-16 · 2005

The information based similarity index provides a new tool to measure the similarity between datasets based on their information content and may have a wide range of applications in the large-scale analysis of genomic databases.

Reply to Comment on 'Linguistic analysis of the human heartbeat using frequency and rank order statistics'

Yang AC, Hseu SS, Yien HW, Goldberger AL, Peng CK

Physical Review Letters, 93 · 2004

Reply defending the information-based dissimilarity index for heartbeat dynamics, clarifying that it captures structure beyond conventional mean/variance statistics of heart rate.

Multimodal pressure-flow method to assess dynamics of cerebral autoregulation in stroke and hypertension

Novak V, Yang AC, Lepicovsky L, Goldberger AL, Lipsitz LA, Peng CK

Biomedical engineering online, 3(1): 39 · 2004

This study evaluated the effects of stroke on regulation of cerebral blood flow in response to fluctuations in systemic blood pressure (BP).

Linguistic analysis of the human heartbeat using frequency and rank order statistics

Yang AC, Hseu SS, Yien HW, Goldberger AL, Peng CK

Physical review letters, 90(10): 108103 · 2003

Complex physiologic signals may carry unique dynamical signatures that are related to their underlying mechanisms.

Information categorization approach to literary authorship disputes

Yang AC, Peng CK, Yien HW, Goldberger AL

Physica A: Statistical Mechanics and its Applications, 329(3-4): 473-483 · 2003

An information-based similarity index, derived from symbolic-dynamics methods used for physiologic signals, is applied to resolve disputed literary authorship by quantifying the statistical structure of texts.

Prediction of paroxysmal atrial fibrillation by footprint analysis

Yang AC, Yien HW

Computers in Cardiology, 28: 401-404 · 2001

A symbolic-dynamics 'footprint' algorithm applied to single-channel ECG to predict the onset of paroxysmal atrial fibrillation, providing a fully automatic prediction tool based on RR-interval mapping.